Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
Type:
Grant
Filed:
March 27, 2014
Date of Patent:
December 22, 2015
Assignee:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Type:
Grant
Filed:
June 7, 2012
Date of Patent:
November 24, 2015
Assignee:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Giuseppe Alvaro, Anne Decor, Dieter Hamprecht, Agostino Marasco
Abstract: The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
Type:
Application
Filed:
May 22, 2013
Publication date:
April 23, 2015
Applicant:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
Type:
Application
Filed:
March 27, 2014
Publication date:
January 15, 2015
Applicant:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Giuseppe ALVARO, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
Type:
Grant
Filed:
December 6, 2010
Date of Patent:
May 13, 2014
Assignee:
Autifony Therapeutics Limited
Inventors:
Giuseppe Alvaro, Anne Décor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Type:
Application
Filed:
June 7, 2012
Publication date:
April 17, 2014
Applicant:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Giuseppe Alvaro, Anne Decor, Dieter Hamprecht, Agostino Marasco
Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Type:
Application
Filed:
December 6, 2011
Publication date:
October 10, 2013
Applicant:
AUTIFONY THERAPEUTICS LIMITED
Inventors:
Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large