Patents Assigned to AUTODISPLAY BIOTECH GMBH
  • Surface display of functional proteins in a broad range of gram negative bacteria
    Patent number: 10683509
    Abstract: The present invention relates to a method for the surface display of a recombinant polypeptide on the surface of a host cell, said method comprising the steps: (a) providing a host cell transformed with a nucleic acid fusion operatively linked with an expression control sequence, said nucleic acid fusion comprising: (i) a portion encoding a signal peptide, (ii) a portion encoding the recombinant polypeptide to be displayed, (iii) a portion encoding a transmembrane linker, and (iv) a portion encoding the trans porter domain of an EhaA protein, and (b) culturing the host cell under conditions wherein the nucleic acid fusion is expressed and the expression product comprising the recombinant polypeptide is displayed on the surface of the host cell.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 16, 2020
    Assignee: Autodisplay Biotech GmbH
    Inventors: Joachim Jose, Mark George Teese, Shanna Sichwart, Iasson Tozakidis
  • Method for binding a recombinant polypeptide to a carrier
    Patent number: 9482663
    Abstract: The present invention refers to a method for binding a recombinant polypeptide to a carrier, wherein a layer is bound to a carrier, and the layer comprises a recombinant polypeptide on the surface distal to the carrier.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: November 1, 2016
    Assignee: Autodisplay Biotech GmbH
    Inventors: Joachim Jose, Jae-Chul Pyun
  • IMPROVED SURFACE DISPLAY OF FUNCTIONAL PROTEINS IN A BROAD RANGE OF GRAM NEGATIVE BACTERIA
    Publication number: 20160108407
    Abstract: The present invention relates to a method for the surface display of a recombinant polypeptide on the surface of a host cell, said method comprising the steps: (a) providing a host cell transformed with a nucleic acid fusion operatively linked with an expression control sequence, said nucleic acid fusion comprising: (i) a portion encoding a signal peptide, (ii) a portion encoding the recombinant polypeptide to be displayed, (iii) a portion encoding a transmembrane linker, and (iv) a portion encoding the trans porter domain of an EhaA protein, and (b) culturing the host cell under conditions wherein the nucleic acid fusion is expressed and the expression product comprising the recombinant polypeptide is displayed on the surface of the host cell.
    Type: Application
    Filed: June 4, 2014
    Publication date: April 21, 2016
    Applicant: AUTODISPLAY BIOTECH GMBH
    Inventors: Joachim JOSE, Mark George TEESE, Shanna SICHWART, Iasson TOZAKIDIS
  • SURFACE DISPLAY OF POLYPEPTIDES CONTAINING A METAL PORPHYRIN OR A FLAVIN
    Publication number: 20140011706
    Abstract: The present invention relates to a method for the display of recombinant functional polypeptides containing a prosthetic group selected from metal porphyrin and flavin containing groups on the surface of a host cell using the transporter domain of an autotransporter.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 9, 2014
    Applicant: Autodisplay Biotech GMBH
    Inventors: Stephanie Schumacher, Rita Bernhardt, Frank Hannemann, Joachim Jose
  • METHOD FOR BINDING A RECOMBINANT POLYPEPTIDE TO A CARRIER
    Publication number: 20120264144
    Abstract: The present invention refers to a method for binding a recombinant polypeptide to a carrier, wherein a layer is bound to a carrier, and the layer comprises a recombinant polypeptide on the surface distal to the carrier.
    Type: Application
    Filed: September 9, 2010
    Publication date: October 18, 2012
    Applicant: AUTODISPLAY BIOTECH GMBH
    Inventors: Joachim Jose, Jae-Chul Pyun