Patents Assigned to Autotac Inc.
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Patent number: 12383624Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.Type: GrantFiled: February 15, 2023Date of Patent: August 12, 2025Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AUTOTAC INC.Inventors: Yong Tae Kwon, Chang Hoon Ji, Srinivasrao Ganipisetti, Hee Yeon Kim, Su Ran Mun, Chan Hoon Jung, Eui Jung Jung, Ki Woon Sung, Hyun Tae Kim, Jeong Eun Na, Eun Hye Jeong, Ji Eun Lee, Min Ju Lee, Chang Min Park, Su Jin Kim
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Patent number: 12129218Abstract: The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.Type: GrantFiled: July 24, 2019Date of Patent: October 29, 2024Assignee: AUTOTAC INC.Inventors: Yong Tae Kwon, Chang Hoon Ji, Srinivasrao Ganipisetti, Hee Yeon Kim, Su Ran Mun, Chan Hoon Jung, Eui Jung Jung, Ki Woon Sung
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Patent number: 11981618Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.Type: GrantFiled: July 24, 2019Date of Patent: May 14, 2024Assignee: AUTOTAC INC.Inventors: Yong Tae Kwon, Chang Hoon Ji, Srinivasrao Ganipisetti, Hee Yeon Kim, Su Ran Mun, Chan Hoon Jung, Eui Jung Jung, Ki Woon Sung
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Patent number: 11753376Abstract: The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.Type: GrantFiled: March 18, 2022Date of Patent: September 12, 2023Assignees: AUTOTAC INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Yong Tae Kwon, Hyun Tae Kim, Jeong Eun Na, Chang Hoon Ji, Chang An Jung
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Publication number: 20230190938Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.Type: ApplicationFiled: February 15, 2023Publication date: June 22, 2023Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, PROTECH CO., LTD., AUTOTAC INC.Inventors: Yong Tae Kwon, Chang Hoon Ji, Srinivasrao Ganipisetti, Hee Yeon Kim, Su Ran Mun, Chan Hoon Jung, Eui Jung Jung, Ki Woon Sung, Hyun Tae Kim, Jeong Eun Na, Eun Hye Jeong, Ji Eun Lee, Min Ju Lee, Chang Min Park, Su Jin Kim
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Publication number: 20220402873Abstract: Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.Type: ApplicationFiled: September 21, 2020Publication date: December 22, 2022Applicants: AUTOTAC INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Yong Tae KWON, Chang Hoon JI, Hyun Tae KIM, Jeong Eun NA, Hee Yeon KIM, Min Ju LEE
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Publication number: 20220298113Abstract: The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.Type: ApplicationFiled: March 18, 2022Publication date: September 22, 2022Applicants: AUTOTAC INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Yong Tae KWON, Hyun Tae KIM, Jeong Eun NA, Chang Hoon JI, Chang An JUNG
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Patent number: 5524329Abstract: A tack-off system for cleaning vehicular bodies eliminates the presence of exposed, flexible conduit at locations above the path of travel of the vehicle therethrough. Additionally, the apparatus includes a positioning system which allows the tack-off brushes to be moved in relation to the vehicular bodies, without changing the positional orientation of the brush assembly with regard thereto. Also, the system includes a vortex enhanced plenum utilized to evacuate ambient air and contaminant particles.Type: GrantFiled: January 4, 1995Date of Patent: June 11, 1996Assignee: Autotac Inc.Inventor: Dennis Schmalzel