Abstract: System and methods for therapy involving the use of three-dimensional articles of manufacture having printed media at predetermined locations thereon to overcome a therapeutic issue, such as (but not necessarily limited to) fear, phobias, trauma, addiction, grief, depression, feelings of loss, physical pain and diabetic neuropathy. By using the system and methods of the present invention while focusing on emotional and/or physical pain associated with a therapeutic issue, both hemispheres of the brain are activated and random stimulation via place or grid cells and their associated complex circuits occur, which collectively causes or creates new neural connections in the brain of the patient to thereby diminish or even resolve the emotional and/or physical pain associated with the therapeutic issue.