Patents Assigned to Avalon Pharmaceuticals
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Publication number: 20100249111Abstract: Chemical agents, such as derivatives of hydroxy benzene moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.Type: ApplicationFiled: April 25, 2008Publication date: September 30, 2010Applicant: AVALON PHARMACEUTICALSInventors: Norman E. Ohler, Jeffrey W. Watthey, Jeffrey Strovel, Sheela K. Chellappan
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Publication number: 20080305493Abstract: Methods for identifying antineoplastic agents by using their ability to modify expression of specific genes or the biological activity of polypeptides encoded by such genes, wherein said genes are located in specific chromosomal regions, called amplicons, or regions of interest, and the presence of such amplified regions within a cancerous cell, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions using these methods. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs), or amplicons, as pharmacodynamic/pharmacogenetic/surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types.Type: ApplicationFiled: March 8, 2005Publication date: December 11, 2008Applicant: AVALON PHARMACEUTICALSInventors: Jeffrey W. Strovel, Colyn B. Cain, Stephen K. Horrigan, Meena Augustus
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Patent number: 7427473Abstract: Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.Type: GrantFiled: February 24, 2005Date of Patent: September 23, 2008Assignee: Avalon Pharmaceuticals, Inc.Inventors: Jeffrey W. Strovel, David Bol, Paul E. Young
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Publication number: 20070270504Abstract: Methods for identifying compounds having similar biological activity based on similarity in genetic expression profile in cells contacted with one or more of said compounds, along with specifically identified compounds, are disclosed.Type: ApplicationFiled: June 17, 2004Publication date: November 22, 2007Applicant: AVALON PHARMACEUTICALS, INC.Inventors: Paul Young, Qin Zong, Stephen Horrigan
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Publication number: 20070059697Abstract: Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including detecting changes in levels of gene copy number and/or level of amplification of the said gene, or sets of genes, to detect and/or diagnose the cancer. Methods for detecting or determining functionally related genes, as well as methods for treating cancer based on targeting expression products of such genes, determining genes involved in the cancerous process and the success and/or response rates and survival statistics for cancer patients on treatment are encompassed by the invention.Type: ApplicationFiled: April 15, 2004Publication date: March 15, 2007Applicant: AVALON PHARMACEUTICALS, INCInventors: Jeffrey Strovel, Colyn Cain, Stephen Horrigan, Meena Augustus
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Patent number: 7094791Abstract: Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.Type: GrantFiled: July 31, 2003Date of Patent: August 22, 2006Assignee: Avalon Pharmaceuticals, Inc.Inventors: Wieslaw M. Cholody, Valentina Petukhova, Sean O'Brien, Norman Ohler, Stanislaw Pikul
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Patent number: 6548539Abstract: Compounds of the general structure according to Formula (I) wherein R1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl; R2 is selected from alkyl, alkenyl, alkyny, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; R3 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; W is selected from Ch2, O and S; n is 0 to about 3: X is selected from S or O; Y, if present, is selected from a bond, aryl, NH, NR, O or S, where R3 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; and Z, if present, can represent a bond or is selected from lower alkyl, O or S are disclosed. Also disclosed are uses of such compounds for treating a variety of disease conditions, including cancer.Type: GrantFiled: March 5, 2002Date of Patent: April 15, 2003Assignee: Avalon PharmaceuticalsInventors: Stanislaw Pikul, Daniel R. Soppet, Paul E. Young