Abstract: Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.
Type:
Grant
Filed:
February 24, 2005
Date of Patent:
September 23, 2008
Assignee:
Avalon Pharmaceuticals, Inc.
Inventors:
Jeffrey W. Strovel, David Bol, Paul E. Young
Abstract: Methods for identifying compounds having similar biological activity based on similarity in genetic expression profile in cells contacted with one or more of said compounds, along with specifically identified compounds, are disclosed.
Abstract: Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including detecting changes in levels of gene copy number and/or level of amplification of the said gene, or sets of genes, to detect and/or diagnose the cancer. Methods for detecting or determining functionally related genes, as well as methods for treating cancer based on targeting expression products of such genes, determining genes involved in the cancerous process and the success and/or response rates and survival statistics for cancer patients on treatment are encompassed by the invention.
Type:
Application
Filed:
April 15, 2004
Publication date:
March 15, 2007
Applicant:
AVALON PHARMACEUTICALS, INC
Inventors:
Jeffrey Strovel, Colyn Cain, Stephen Horrigan, Meena Augustus
Abstract: Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
Type:
Grant
Filed:
July 31, 2003
Date of Patent:
August 22, 2006
Assignee:
Avalon Pharmaceuticals, Inc.
Inventors:
Wieslaw M. Cholody, Valentina Petukhova, Sean O'Brien, Norman Ohler, Stanislaw Pikul