Patents Assigned to Avanir Pharmaceuticals
  • Methods for the synthesis of deuterated dextromethorphan
    Patent number: 11845731
    Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: December 19, 2023
    Assignee: AVANIR PHARMACEUTICALS, INC.
    Inventors: Matt Johnson, Cunxiang Zhao, Weihua Meng, Zhijun Lu, Yan Li
  • Methods for the synthesis of deuterated dextromethorphan
    Patent number: 10865187
    Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: December 15, 2020
    Assignee: Avanir Pharmaceuticals, Inc.
    Inventors: Matt Johnson, Cunxiang Zhao, Weihua Meng, Zhijun Lu, Yan Li
  • Methods for the synthesis of deuterated dextromethorphan
    Patent number: 10730841
    Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: August 4, 2020
    Assignee: Avanir Pharmaceuticals, Inc.
    Inventors: Matt Johnson, Cunxiang Zhao, Weihua Meng, Zhijun Lu, Yan Li
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20140045880
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicant: Avanir Pharmaceuticals, Inc.
    Inventors: Gerald Yakatan, James Berg, Laura E. Pope, Richard A. Smith
  • METHOD OF REDUCING CNS AND GASTROINTESTINAL SIDE AFFECTS ASSOCIATED WITH LONG-TERM, DEXTROMETHORPHAN/LOW-DOSE QUINIDINE COMBINATION THERAPY
    Publication number: 20130190346
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine. This invention also provides methods of reducing CNS and gastrointestinal side effects associated with a long term, dextromethorphan/low-dose quinidine combination therapy.
    Type: Application
    Filed: January 29, 2013
    Publication date: July 25, 2013
    Applicant: Avanir Pharmaceuticals, Inc.
    Inventor: Avanir Pharmaceuticals, Inc.
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF DEPRESSION, ANXIETY, AND NEURODEGENERATIVE DISORDERS
    Publication number: 20130137714
    Abstract: Pharmaceutical compositions and methods for treating depression, anxiety, and neurodegenerative diseases and cognitive disorders, such as dementia and Alzheimer's disease, by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 30, 2013
    Applicant: AVANIR PHARMACEUTICALS, INC.
    Inventor: AVANIR PHARMACEUTICALS, INC.
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20130072517
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 21, 2013
    Applicant: Avanir Pharmaceuticals, Inc.
    Inventor: Avanir Pharmaceuticals, Inc.
  • Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
    Patent number: 8227484
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: July 24, 2012
    Assignee: Avanir Pharmaceuticals, Inc.
    Inventors: Gerald Yakatan, James Berg, Laura Pope, Richard Alan Smith
  • Pharmaceutical Compositions Comprising Dextromethorphan and Quinidine for the Treatment of Neurological Disorders
    Publication number: 20120165363
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: March 8, 2012
    Publication date: June 28, 2012
    Applicant: AVANIR PHARMACEUTICALS, INC.
    Inventors: Gerald YAKATAN, James Berg, Laura E. Pope, Richard A. Smith
  • METHOD OF REDUCING CNS AND GASTROINTESTINAL SIDE AFFECTS ASSOCIATED WITH LONG-TERM DEXTROMETHORPHAN/LOW-DOSE QUINIDINE COMBINATION THERAPY
    Publication number: 20110212987
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine. This invention also provides methods of reducing CNS and gastrointestinal side effects associated with a long term, dextromethorphan/low-dose quinidine combination therapy.
    Type: Application
    Filed: August 10, 2010
    Publication date: September 1, 2011
    Applicant: AVANIR PHARMACEUTICALS, INC.
    Inventors: Gregory J. Flesher, Randall E. Kaye
  • Pharmaceutical Compositions Comprising Dextromethorphan and Quinidine for the Treatment of Depression, Anxiety, and Neurodegenerative Disorders
    Publication number: 20110021552
    Abstract: Pharmaceutical compositions and methods for treating depression, anxiety, and neurodegenerative diseases and cognitive disorders, such as dementia and Alzheimer's disease, by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: June 22, 2010
    Publication date: January 27, 2011
    Applicant: AVANIR PHARMACEUTICALS, INC.
    Inventor: James Berg
  • Method for screening an agent that modulates activity of macrophage migration inhibitory factor
    Patent number: 7732146
    Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: June 8, 2010
    Assignee: Avanir Pharmaceuticals
    Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K.C.
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20100137352
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: February 3, 2010
    Publication date: June 3, 2010
    Applicant: AVANIR PHARMACEUTICALS, INC.
    Inventors: Gerald YAKATAN, James Berg, Laura E. Pope, Richard A. Smith
  • Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
    Patent number: 7659282
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Grant
    Filed: January 12, 2005
    Date of Patent: February 9, 2010
    Assignee: Avanir Pharmaceuticals, Inc.
    Inventors: Gerald Yakatan, James Berg, Laura E. Pope, Richard A. Smith
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF DEPRESSION, ANXIETY, AND NEURODEGENERATIVE DISORDERS
    Publication number: 20090111846
    Abstract: Pharmaceutical compositions and methods for treating depression, anxiety, and neurodegenerative diseases and cognitive disorders, such as dementia and Alzheimer's disease, by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: July 29, 2008
    Publication date: April 30, 2009
    Applicant: Avanir Pharmaceuticals
    Inventor: James Berg
  • Method for screening an agent that modulates activity of macrophage migration inhibitory factor
    Patent number: 7514225
    Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: April 7, 2009
    Assignee: Avanir Pharmaceuticals
    Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20090082384
    Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
    Type: Application
    Filed: November 25, 2008
    Publication date: March 26, 2009
    Applicant: Avanir Pharmaceuticals
    Inventors: Gerald Yakatan, James Berg, Laura E. Pope, Richard A. Smith
  • Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
    Patent number: 7432374
    Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 7, 2008
    Assignee: Avanir Pharmaceuticals
    Inventors: Federico C. A. Gaeta, Andrew Baird, Jerry Anchin, Wenbin Ying, Robert Florkiewicz, Jagadish Sircar, Sunil Kumar K. C.
  • TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES
    Publication number: 20080139551
    Abstract: treatment of a variety of disorders, including the treatment of pathological conditions associated with tumor necrosis factor alpha. The inhibitors of tumor necrosis factor alpha have the following structures: including stereoisomers, pharmaceutically acceptable salts, and solvates thereof, wherein substituents are as defined herein. Compositions containing an inhibitor of tumor necrosis factor alpha in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
    Type: Application
    Filed: August 21, 2007
    Publication date: June 12, 2008
    Applicants: AVANIR PHARMACEUTICALS, NOVARTIS PHARMA GMBH
    Inventors: Jagadish Sircar, Sunil Kumar, Timothy James Davis, Wenbin Ying, Peter Nussbaumer, Andreas Billich
  • Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
    Patent number: 7375118
    Abstract: The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: May 20, 2008
    Assignee: Avanir Pharmaceuticals
    Inventors: Jagadish C. Sircar, Jailall Ramnauth, Mark L. Richards