Abstract: The present invention relates to a therapeutic composition to protect a mammal from B. henselae infection that includes an isolated B. henselae antigen and an adjuvant comprising a phosphazene polymer. Also included is a method to use such a therapeutic composition to protect a mammal from B. henselae infection. One embodiment is a method to protect a human from cat scratch disease by administering such a therapeutic composition to a domestic cat in contact with the human. The present invention also includes a method to produce such a therapeutic composition.

Abstract: Sarcoidosis is associated with CD4.sup.+ T lymphocytes which express the T cell receptor V.sub..alpha. 2.3 chain. Thus, a method for diagnosing sarcoidosis is provided which comprises contacting cells of a subject with a first monoclonal antibody, or an antigen-binding fragment or derivative, specific for an epitope of the variable region of the T cell receptor V.sub..alpha. 2.3 chain and detecting the binding of the antibody. Also provided is a method for treating sarcoidosis in which a monoclonal antibody, or an antigen-binding fragment or derivative thereof, specific for an epitope of the variable region of the T cell receptor V.sub..alpha. 2.3 chain is administered. Sarcoidosis is also treated by administering a therapeutically effective amount of a protein or a peptide comprising an amino acid sequence of the variable region of the T cell receptor V.sub..alpha. 2.3 chain, or a functional derivative of the protein or peptide, or an antisense oligonucleotide which is complementary to the T cell receptor V.