Patents Assigned to Avantium International B.V.
-
Patent number: 8084267Abstract: A laboratory degradation test system for testing degradation of a test specimen in a test fluid flow includes a reactor assembly, which reactor assembly comprises: a reactor vessel, the reactor vessel having a reaction space, an inlet and an outlet and a specimen holder for retaining a test specimen inside the reactor vessel, a heater for heating the reactor vessel, a fluid circulation system generating a test fluid flow over the test specimen, which fluid circulation system comprises: a circulation line which extends between the outlet of the reactor vessel and the inlet of the reactor vessel, which circulation line is arranged outside the reactor vessel, a pump for providing fluid circulation through the circulation line and the reactor vessel, which pump is arranged in the circulation line. The volume available to the test fluid inside the reaction space after insertion of the degradation test specimen is less than or equal to 10 ml.Type: GrantFiled: March 19, 2008Date of Patent: December 27, 2011Assignee: Avantium International B.V.Inventors: Gerardus Johannes Maria Gruter, Roelandus Hendrikus Wilhelmus Moonen, Jan Peter de Jong, David Michael Knowles
-
Patent number: 7997297Abstract: The invention relates to a system for performing parallel chemical experiments. The system comprises an array of parallel flow through reactors each comprising a reaction chamber, a reactor inlet and a reactor outlet connected to the reactor chamber. Downstream of each reactor a corresponding active pressure regulating arrangement is provided for actively regulating the reactor pressure. The pressure regulating arrangement comprises a passage for reactor effluent with an inlet connected to the reactor outlet and an outlet for discharging reactor effluent at a reduced pressure with respect to the reactor pressure.Type: GrantFiled: April 4, 2005Date of Patent: August 16, 2011Assignee: Avantium International B.V.Inventors: Martin Smit, Gerardus Johannes Maria Gruter
-
Patent number: 7916294Abstract: A system for determining a solubility of a substance comprises a holder to hold a sample comprising an amount of the substance and an amount of the solvent system. The system further comprises a temperature conditioner to alter a temperature of the sample, an optical measurement device to measure an optical parameter of the sample and a control device to control at least the temperature conditioner and the optical measurement device. The control device may be programmed to alter the temperature of the sample by the temperature conditioner, measure the optical parameter of the sample by the optical measurement device, and determine the solubility of the substance from a change of the optical parameter of the sample as a function of the temperature.Type: GrantFiled: September 21, 2006Date of Patent: March 29, 2011Assignee: Avantium International B.V.Inventors: Emilio René Bodenstaff, Danny Dirk Pieter Willem Stam, Benjamin McKay, Mimoun Lamkadmi
-
Publication number: 20110009295Abstract: The present invention provides a system, comprising at least one reactor array, comprising at least two reactor vessels (2) a connecting member for fixating the at least two reactor vessels relative to each other (4, 5) at least one reactor block (18) comprising a heating block (20) for heating the reactor vessels (2) the heating block (20) comprising at least two reactor channels for receiving the at least two reactor vessels (2) wherein the heating block (20) is constructed of a material having a thermal expansion coefficient <=1×10e?5 K-I (at 293K). In an embodiment the heating block is substantially entirely constructed of graphite.Type: ApplicationFiled: June 27, 2007Publication date: January 13, 2011Applicant: AVANTIUM INTERNATIONAL B.V.Inventors: Emilio Rene Bodenstaff, Adrianus Hendricus Joseph Franciscus de Keijzer, Tom Nijbacker
-
Patent number: 7766979Abstract: This invention relates to a method for phase transformation in molecular solids and the use of high-energy mills of said method.Type: GrantFiled: January 26, 2005Date of Patent: August 3, 2010Assignee: Avantium International B.V.Inventors: Tanja Bendele, Claudia Weidenthaler, Michael Felderhoff
-
Patent number: 7732211Abstract: The present invention relates to a method for screening of polycondensation catalysts, wherein at least two polycondensation catalysis reactions are performed simultaneously under substantially equivalent conditions in at least two reaction cells which are present in one and the same room, using a sample comprising material to be polycondensated and a catalyst to be screened, and wherein the performances of the catalysts are analyzed. The present invention further relates to an apparatus suitable for performing the method.Type: GrantFiled: October 12, 2001Date of Patent: June 8, 2010Assignee: Avantium International B.V.Inventors: Donald Ross Kelsey, Kathleen Suzanne Kiibler
-
Publication number: 20100105147Abstract: A laboratory degradation test system for testing degradation of a test specimen in a test fluid flow includes a reactor assembly, which reactor assembly comprises: a reactor vessel, the reactor vessel having a reaction space, an inlet and an outlet and a specimen holder for retaining a test specimen inside the reactor vessel, a heater for heating the reactor vessel, a fluid circulation system generating a test fluid flow over the test specimen, which fluid circulation system comprises: a circulation line which extends between the outlet of the reactor vessel and the inlet of the reactor vessel, which circulation line is arranged outside the reactor vessel, a pump for providing fluid circulation through the circulation line and the reactor vessel, which pump is arranged in the circulation line. The volume available to the test fluid inside the reaction space after insertion of the degradation test specimen is less than or equal to 10 ml.Type: ApplicationFiled: March 19, 2008Publication date: April 29, 2010Applicant: AVANTIUM INTERNATIONAL B.V.Inventors: Gerardus Johannes Maria Gruter, Roelandus Hendrikus Wilhelmus Moonen, Jan Peter de Jong, David Michael Knowles
-
Patent number: 7702071Abstract: A method for successively performing a powder diffraction analysis of at least two powder samples being contained in sample holding means. Use is made of an apparatus comprising:—a source of radiation being adapted to direct a radiation beam to a power sample,—a detector for detecting diffraction radiation of a powder sample,—a drive means associated with said sample holding means for effecting a movement of an irradiated powder sample during irradiation and detection. The method comprises the steps of irradiating a powder sample and detecting the diffraction radiation of the powder sample, arranging a further powder sample such that said radiation beam is directed to said further powder sample, and irradiating said further powder sample and detecting the diffraction radiation of said further sample. During irradiation and detecting of each sample the drive means effect a movement of the irradiated sample with respect to the radiation beam for the purpose of improving particle statistics.Type: GrantFiled: January 15, 2003Date of Patent: April 20, 2010Assignee: Avantium International B.V.Inventors: Erwin Blomsma, Adriaan Jan van Langevelde
-
Publication number: 20100087312Abstract: Described is a method for the preparation of a chromium-free catalyst comprising Cu and at least one second metal in metallic or oxidic form, comprising the steps of a) preparing a final solution comprising ions of Cu and of at least one second metal, said final solution additionally comprising ions of a complexing agent and having a pH of above 5; b) contacting said final solution with inert carrier to form a final solution/carrier combination; c) optionally, drying the final solution/carrier combination; d) calcining the final solution/carrier combination obtained in step c) or d) to yield Cu and the at least one second metal in oxidic form; and e) reducing at least part of the thus obtained oxidic Cu on the carrier. Further, a catalyst obtainable by the said method as well as uses thereof are described.Type: ApplicationFiled: December 7, 2009Publication date: April 8, 2010Applicants: AVANTIUM INTERNATIONAL B.V., UNIVERSITI MALAYAInventors: André Harmen SIJPKES, Nelleke van der PUIL, Peter John van den BRINK, Sharifah Bee ABDUL HAMID, Adrianus Hendricus Joseph Franciscus de KEIJZER
-
Patent number: 7625526Abstract: A reactor assembly for analysing the effluent stream from at least one flow-through reactor, The reactor includes a flow-through reactor for performing at least one chemical reaction. The flow-through reactor includes a reaction chamber including a reaction zone, the reaction chamber being connected to a reactor inlet for a reactant, upstream of the reaction zone and a reactor outlet for the effluent stream from the reaction zone, downstream of the reaction zone; and an analyser for subjecting the effluent stream to an analysing procedure, each reactor outlet being connected to an analyser by an effluent conduit. The reactor assembly further includes a dilution fluid supply member for adding a dilution fluid to the effluent stream, downstream of the reaction zone.Type: GrantFiled: May 13, 2002Date of Patent: December 1, 2009Assignee: Avantium International B.V.Inventors: Peter John van den Brink, Maarten Bracht, Gerardus Johannes Maria Gruter, Rene de Ruiter, Bashir Husein Harji
-
Patent number: 7608222Abstract: An assembly and method for performing parallel chemical experiments, in particular crystallisation experiments. The assembly has a main body having a first and a second face on opposite sides thereof. Multiple bores extend through said main body between said first and second face. Tubular liners are provided having openings at opposite ends thereof, each liner removably fitting in a bore in the main body. First closure means close the openings of the liners at the first face of the main body. Second closure means close the openings of the liners at the second face of the main body. The first and second closure means are fastenable to said main body, so that an experimentation chamber is defined within each liner.Type: GrantFiled: August 2, 2003Date of Patent: October 27, 2009Assignee: Avantium International B.V.Inventors: Erwin Blomsma, Adriaan Jan van Langevelde, Danny Dirk Peter Willem Stam
-
Publication number: 20090205412Abstract: The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being provided with a filter having pores, which filter is arranged at a distance below the open upper end, each of the wells having an upper inner wall part above the filter that has a fluid contact surface and each filter having a top filter surface, at least both the fluid contact surface of the well and the top filter surface being of a material that is at least substantially inert for organic and/or aqueous solvents and/or mixtures of organic and aqueous solvents, providing one or more substances and one or more solvents in at least one of the wells of the well plate, applying conditions to dissolve the one or more substances in the one or more solvents; applying conditions for crystallizing at least a part of the suType: ApplicationFiled: July 17, 2006Publication date: August 20, 2009Applicant: AVANTIUM INTERNATIONAL B.V.Inventors: Danny Dirk Pieter Willem Stam, Adrianus Hendricus Joseph Franciscus de Keijzer, Emilio Rene Bodenstaff, Mimoun Lamkadmi
-
Patent number: 7531139Abstract: The system comprises a tubular vessel allowing a flow of fluid through said vessel and an assembly for housing said vessel. The assembly comprises a base block having a first channel formed therein for removably housing the vessel, said first channel having first and second channel openings allowing introduction and/or discharge of a fluid into and from said first channel. The assembly also comprises a cover element having a bottom surface being releasably attachable to the first face of the base block. A first sealing element is provided between the first face of the base block and the bottom surface of the cover element, the first sealing element surrounding the first channel opening completely, and thereby sealing gastight around said first channel opening between the cover element and the base block. The system further comprises a second sealing element located in the first channel, said second sealing element sealing gastight against the inside of the first channel and the outside of the vessel.Type: GrantFiled: November 7, 2003Date of Patent: May 12, 2009Assignee: Avantium International B.V.Inventors: Peter John van den Brink, Maarten Bracht, Bashir Husein Harji
-
Patent number: 7488452Abstract: The system comprises a flow through reaction vessel having an inlet, an outlet and a reaction zone intermediate said inlet and outlet. The system further comprises reagent feed means for introducing one or more reagents into said vessel, said one or more reagents forming one or more reaction products in said reaction zone. Said reagent feed means at least include a liquid feed means for introducing a liquid into said inlet of said vessel. The vessel has a liquid evaporation zone intermediate said inlet and said reaction zone. Said liquid evaporation zone comprises an evaporation structure contacting said liquid and providing a liquid residence time in said liquid evaporation zone improving evaporation of said liquid.Type: GrantFiled: May 13, 2002Date of Patent: February 10, 2009Assignee: Avantium International B.V.Inventors: Peter John van den Brink, Maarten Bracht
-
Publication number: 20080252886Abstract: A system for determining a solubility of a substance comprises a holder to hold a sample comprising an amount of the substance and an amount of the solvent system. The system further comprises a temperature conditioner to alter a temperature of the sample, an optical measurement device to measure an optical parameter of the sample and a control device to control at least the temperature conditioner and the optical measurement device. The control device may be programmed to alter the temperature of the sample by the temperature conditioner, measure the optical parameter of the sample by the optical measurement device, and determine the solubility of the substance from a change of the optical parameter of the sample as a function of the temperature.Type: ApplicationFiled: September 21, 2006Publication date: October 16, 2008Applicant: AVANTIUM INTERNATIONAL B.V.Inventors: Emilio Rene Bodenstaff, Danny Dirk Pieter Willem, Benjamin McKay, Mimoun Lamkadmi
-
Publication number: 20080159927Abstract: The invention relates to a system for performing parallel chemical experiments. The system comprises an array of parallel flow through reactors each comprising a reaction chamber, a reactor inlet and a reactor outlet connected to the reactor chamber. Downstream of each reactor a corresponding active pressure regulating arrangement is provided for actively regulating the reactor pressure. The pressure regulating arrangement comprises a passage for reactor effluent with an inlet connected to the reactor outlet and an outlet for discharging reactor effluent at a reduced pressure with respect to the reactor pressure.Type: ApplicationFiled: April 4, 2005Publication date: July 3, 2008Applicant: AVANTIUM INTERNATIONAL B.V.Inventors: Martin Smit, Gerardus Johannes Maria Gruter
-
Patent number: 7375807Abstract: A system for the preparation and handling of multiple solid state samples, in particular for spectroscopic and microscopic analysis. The system comprises a sample holder assembly for multiple solid-state samples. The sample holder assembly comprises a sample holding body having first and second sides (3a, 4a), provided with multiple sample receiving open-ended bores (5) extending through said body between said first and second sides, each bore (5) having a first opening at the first side and a second opening at the second side. Furthermore a closure body (10) is provided adapted to be mounted against the second side of the sample holding body, said closure body (10) having a closure side adapted to rest against the second side of the sample holding body for closing off the second openings of the bores (5) in said sample holding body. Compacting (23) means are provided for compacting samples filled in bores (5) of the sample holding body as these bores are closed off on the second side by the closure body.Type: GrantFiled: July 15, 2002Date of Patent: May 20, 2008Assignee: Avantium International B.V.Inventors: Peter John van den Brink, André Harmen Sijpkes
-
Patent number: 7345202Abstract: The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1,R2)N—SO3H, wherein: R1 and R2, being the same or different, represent a hydrogen atom or a C1-C30 linear, branched or cyclic (hetero)-aliphatic or (hetero)-aromatic group, provided that R1 and R2 are not both hydrogen and that at least one of the R1 and R2 groups is chiral. Further, methods for resolving enantiomeric mixtures are disclosed.Type: GrantFiled: June 7, 2002Date of Patent: March 18, 2008Assignee: Avantium International B.v.Inventors: Alan Arthur Smith, Franciscus Wilhelmus Petrus Damen, George Johannes Theodorus Kuster
-
Publication number: 20070207921Abstract: Described is a method for the preparation of a chromium-free catalyst comprising Cu and at least one second metal in metallic or oxidic form, comprising the steps of a) preparing a final solution comprising ions of Cu and of at least one second metal, said final solution additionally comprising ions of a complexing agent and having a pH of above 5; b) contacting said final solution with inert carrier to form a final solution/carrier combination; c) optionally, drying the final solution/carrier combination; d) calcining the final solution/carrier combination obtained in step c) or d) to yield Cu and the at least one second metal in oxidic form; and e) reducing at least part of the thus obtained oxidic Cu on the carrier Further, a catalyst obtainable by the said method as well as uses thereof are describedType: ApplicationFiled: January 21, 2004Publication date: September 6, 2007Applicants: AVANTIUM INTERNATIONAL B.V., UNIVERSITI MALAYAInventors: Andre Sijpkes, Nelieke van der Puil, Peter van den Brink, Sharifah Abdul Hamid, Adrianus Hendricus de Keijzer
-
Publication number: 20070149390Abstract: Described is a method for the preparation of Mo—V—Te—Nb catalyst comprising the steps of a) preparing a slurry comprising ionic species of Mo, V, Te and Nb and an inert carrier by combining the inert carrier in ceramic form with one or more solutions comprising the above metal ionic species; b) drying of the slurry to obtain a particulate product; c) precalcining the dried particulate product at a temperature of 150-350° C. in an oxygen-containing atmosphere; d) calcining the precalcined dried particulate product at a temperature of 350-750° C. in an inert atmosphere to obtain the catalyst. Further, a catalyst obtainable by the said method as well as uses thereof are described.Type: ApplicationFiled: December 18, 2003Publication date: June 28, 2007Applicants: AVANTIUM INTERNATIONAL B.V., UNIVERSITI MALAYAInventors: Andre Sijpkes, Roelandus Hendrikus Moonen, Nelleke van der Puil, Sharifah Bee Abdul Hamid