Abstract: A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an ?-nitrogen protected C?-carboxamide amino acid to a solid support by its side chain, removing the ?-nitrogen protecting group, assembling a peptide chain on said ?-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.
Type:
Grant
Filed:
May 2, 2003
Date of Patent:
April 6, 2010
Assignee:
Avecia Biologics Limited
Inventors:
David John Evans, Dean Steven Anthony Simpkin, Donald Alfred Wellings, Eric Atherton