Patents Assigned to Avecta Limited
  • Vector-free intracellular delivery by reversible permeabilization
    Patent number: 11981915
    Abstract: The invention provides a solution to the problem of transfecting non-adherent cells. Devices and delivery compositions containing ethanol and an isotonic salt solution are used for delivery of compounds and compositions to non-adherent cells.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 14, 2024
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Vector-free delivery of gene editing proteins and compositions to cells and tissues
    Patent number: 11827899
    Abstract: The present subject matter provides a method for delivering a gene editing composition across a plasma membrane of a cell. Related apparatus, system, techniques, compositions, and articles are also described.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 28, 2023
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Electrospray catheter
    Patent number: 11801364
    Abstract: An apparatus includes a catheter, and an electrode and methods of delivering molecules to eukaryotic cells using such an apparatus. The catheter defines a fluidic channel and has a distal opening. The electrode is within the fluidic channel and is spaced a distance from the distal opening of the catheter. The catheter is arranged to prevent direct contact between any electrode of the apparatus and tissue. Related apparatus, systems, techniques and articles are also described.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 31, 2023
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shane Finnegan
  • Delivery across cell plasma membranes
    Patent number: 11447798
    Abstract: Delivering a payload across a plasma membrane of a cell includes providing a population of cells and contacting the population of cells with a volume of an aqueous solution. The aqueous solution includes the payload and alcohol content greater than 5 percent concentration. The volume of the aqueous solution may be a function of exposed surface area of the population of cells, or may be a function of a number of cells in the population of cells. Related compositions, apparatus, systems, techniques, and articles are also described.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 20, 2022
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Delivery across cell plasma membranes
    Patent number: 11332757
    Abstract: Delivering a payload across a plasma membrane of a cell includes providing a population of cells and contacting the population of cells with a volume of an aqueous solution. The aqueous solution includes the payload and alcohol content greater than 5 percent concentration. The volume of the aqueous solution may be a function of exposed surface area of the population of cells, or may be a function of a number of cells in the population of cells. Related compositions, apparatus, systems, techniques, and articles are also described.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: May 17, 2022
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Delivery across cell plasma membranes
    Patent number: 10612042
    Abstract: Delivering a payload across a plasma membrane of a cell includes providing a population of cells and contacting the population of cells with a volume of an aqueous solution. The aqueous solution includes the payload and alcohol content greater than 5 percent concentration. The volume of the aqueous solution may be a function of exposed surface area of the population of cells, or may be a function of a number of cells in the population of cells. Related compositions, apparatus, systems, techniques, and articles are also described.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: April 7, 2020
    Assignee: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Delivery Across Cell Plasma Membranes
    Publication number: 20170356011
    Abstract: Delivering a payload across a plasma membrane of a cell includes providing a population of cells and contacting the population of cells with a volume of an aqueous solution. The aqueous solution includes the payload and alcohol content greater than 5 percent concentration. The volume of the aqueous solution may be a function of exposed surface area of the population of cells, or may be a function of a number of cells in the population of cells. Related compositions, apparatus, systems, techniques, and articles are also described.
    Type: Application
    Filed: October 23, 2015
    Publication date: December 14, 2017
    Applicant: Avectas Limited
    Inventors: Michael Maguire, Shirley O'Dea
  • Phthalocyanines
    Patent number: 6335442
    Abstract: Phthalocyanine compounds substituted by from 1 to 8 substituents of formula (—O—R—O—) wherein R is a 1,2-arylene group are provided. Preferably, the phthalocyanine compounds are substituted by catechol. Additional substituents which may be present include hydrocarlyloxy, hydrocarbylthio, halogen and sulphonic acid or a salt thereof.
    Type: Grant
    Filed: February 3, 1997
    Date of Patent: January 1, 2002
    Assignee: Avecta Limited
    Inventors: Peter Gregory, Stephen James Reynolds