Abstract: N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
Type:
Application
Filed:
September 27, 2005
Publication date:
February 2, 2006
Applicant:
Avenits Pharmaceuticals Inc.
Inventors:
Craig Smith, Michel Rathbone, Margaret Petty, David Rampe