Patents Assigned to Aventis Pharma S.A.
  • 7-substituted aza-indazoles, compositions containing same, production method and use thereof
    Patent number: 8058290
    Abstract: The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: November 15, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Kirsten Bjergarde, Anil Nair, Marcel Patek, Martha Ackerman-Berrier, Martin Smrcina, Eric Bacque, Michel Tabart, Baptiste Ronan, Vincent Leroy, Fabrice Viviani, Mark Dodson, Catherine Souaille
  • Isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses thereof in particular as inhibitors of chaperone protein Hsp90 activities
    Patent number: 8034939
    Abstract: This invention relates to isoindole derivates of Formula I to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 11, 2011
    Assignee: Aventis Pharma S.A..
    Inventors: Patrick Mailliet, Luc Bertin, Didier Benard, Chantal Carrez, François Vallee, Eric Bacque
  • MIXTURES OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20110212915
    Abstract: The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 11, 2011
    Publication date: September 1, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Vesna Biberovic, Luc Grondard, Pierre Mourier, Christian VISKOV
  • Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use
    Patent number: 8008322
    Abstract: The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: August 30, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Baptiste Ronan, Michel Tabart, Frank Halley, Eric Bacque, Catherine Souaille, Antonio Ugolini, Fabrice Viviani
  • Mixtures of sulfated oligosaccharides
    Patent number: 8003623
    Abstract: The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: August 23, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Vesna Biberovic, Luc Grondard, Pierre Mourier, Christian Viskov
  • MIXTURES OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20110201573
    Abstract: The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 9, 2011
    Publication date: August 18, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Vesna Biberovic, Luc Grondard, Pierre Mourier, Christian VISKOV
  • Mutations of the parkin gene, compositions, methods and uses
    Patent number: 7998667
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: August 16, 2011
    Assignees: Aventis Pharma S.A., Institut National Sante et Recherche Medicale
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • Method of treating cancer with docetaxel and doxorubicin
    Patent number: 7994212
    Abstract: Antitumor combinations comprising a taxane and at least one antibiotic for treating neoplastic diseases are described.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: August 9, 2011
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE
    Publication number: 20110190337
    Abstract: The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.
    Type: Application
    Filed: April 11, 2011
    Publication date: August 4, 2011
    Applicant: AVENTIS PHARMA S.A..
    Inventors: Baptiste RONAN, Michel TABART, Frank HALLEY, Eric BACQUE, Catherine SOUAILLE, Antonio UGOLINI, Fabrice VIVIANI
  • Method of treating leukemia with docetaxel and vinca alkaloids
    Patent number: 7989489
    Abstract: Antitumor combinations comprising a taxane and at least one therapeutically useful substance for treating neoplastic diseases are described.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: August 2, 2011
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • OLIGOSACCHARIDE MIXTURES DERIVED FROM HEPARIN, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20110178039
    Abstract: Oligosaccharide mixtures comprising anti-Xa activities of from 190 IU/mg to 450 IU/mg and anti-IIa activities of less than 0.2 IU/mg; and having constituent oligosaccharides with an average molecular weight of from 1800 to 2400 Daltons, constituent oligosaccharides comprise from 2 to 16 saccharide units, a 4,5-unsaturated uronic acid 2-O-sulfate unit at one end, and comprising at least one ?IIa-IIs-Is hexasaccharide sequence are described. Processes for preparing the oligosaccharide mixtures, pharmaceutical compositions and articles of manufacture comprising the oligosaccharide mixtures are described. Methods of treatment and prevention comprising administering the oligosaccharide mixtures are described.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 21, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Volker LAUX, Pierre MOURIER, Christian VISKOV
  • Yeast strains autonomously producing steroids
    Patent number: 7977065
    Abstract: The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: July 12, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Roberto Spagnoli, Tilman Achstetter, Gilles Cauet, Eric Degryse, Bruno Dumas, Denis Pompon, Jacques Winter
  • Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors
    Patent number: 7968566
    Abstract: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: June 28, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Sylvie Wentzler, Youssef El-Ahmad, Bruno Filoche-Romme, Conception Nemecek, Corinne Venot, Augustin Hittinger
  • COMPOSITIONS OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20110152509
    Abstract: Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
    Type: Application
    Filed: August 25, 2010
    Publication date: June 23, 2011
    Applicant: Aventis Pharma S.A.
    Inventors: Christelle PECQUET, Elisabeth Perrin, Christian Viskov
  • CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING THE SAME
    Publication number: 20110144362
    Abstract: The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2?-benzoyloxy-5?,20-epoxy-1-hydroxy-7?, 10?-dimethoxy-9-oxo-tax-11-ene-13?-yl, and to the preparation thereof.
    Type: Application
    Filed: July 16, 2010
    Publication date: June 16, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Pascal Billot, Marielle Dufraigne, Hagit Elmaleh, Alexandre Giuliani, Fabrice Mangin, Patricia Rortais, Lionel Zaske
  • Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
    Patent number: 7956046
    Abstract: Oligosaccharide mixtures comprising anti-Xa activities of from 190 IU/mg to 450 IU/mg and anti-IIa activities of less than 0.2 IU/mg; and having constituent oligosaccharides with an average molecular weight of from 1800 to 2400 Daltons, constituent oligosaccharides comprise from 2 to 16 saccharide units, a 4,5-unsaturated uronic acid 2-O-sulfate unit at one end, and comprising at least one ?IIa-IIs-Is hexasaccharide sequence are described. Processes for preparing the oligosaccharide mixtures, pharmaceutical compositions and articles of manufacture comprising the oligosaccharide mixtures are described. Methods of treatment and prevention comprising administering the oligosaccharide mixtures are described.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: June 7, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Volker Laux, Pierre Mourier, Christian Viskov
  • GALENIC APPLICATIONS OF SELF-EMULSIFYING MIXTURES OF LIPIDIC EXCIPIENTS
    Publication number: 20110104268
    Abstract: A subject-matter of the invention is novel pharmaceutical formulations which make it possible to improve the intestinal absorption of orally administered active principles, their process of preparation and the application of lipid excipients in combination with one or more surfactants and one or more cosurfactants for inhibiting efflux pumps.
    Type: Application
    Filed: August 27, 2010
    Publication date: May 5, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Jean Pachot, Serge Segot Chicq
  • Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Patent number: 7935819
    Abstract: Compounds of formula (I): wherein Ra, Rb, R, X1 and X2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are provided.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: May 3, 2011
    Assignee: Aventis Pharma S.A.
    Inventors: Frank Halley, Youssef El-Ahmad, Victor Certal, Corinne Venot, Anne Dagallier, Hartmut Strobel, Kurt Ritter, Sven Ruf
  • Combination Comprising Combretastatin and Anticancer Agents
    Publication number: 20110054035
    Abstract: This invention relates to therapeutic combinations comprising VEGF Trap and a stilbene derivative, and to methods for treatment of cancer comprising administration of such combinations.
    Type: Application
    Filed: November 9, 2010
    Publication date: March 3, 2011
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Marie-Christine BISSERY, Patricia VRIGNAUD, Marielle CHIRON-BLONDEL, Brigitte DEMERS
  • NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS
    Publication number: 20110046402
    Abstract: The subject of the invention is a method for preparing compounds of general formula (I): in which A, Z, R3 are as defined in the description, and the intermediate compounds for carrying out this method.
    Type: Application
    Filed: October 29, 2010
    Publication date: February 24, 2011
    Applicant: Aventis Pharma S.A.
    Inventors: Denis Prat, Christian Moratille, Francoise Benedetti, Lahlou Nait-Bouda