Patents Assigned to Aventis Pharmaveuticals Inc.
  • Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)
    Patent number: 7405300
    Abstract: The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5?-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: July 29, 2008
    Assignee: Aventis Pharmaveuticals Inc.
    Inventors: John Z. Jiang, Jack Roger Koehl, Shujaath Mehdi, Neil David Moorcroft, Kwon Yon Musick, Philip Marvin Weintraub, Paul Robert Eastwood