Patents Assigned to Aventis Research & Technologies
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Patent number: 7777024Abstract: The invention relates to a process for preparing a conjugate that includes a pentopyranosyl nucleic acid and a biomolecule. The process includes the steps of providing a pentopyranosyl nucleic acid having at least two pentopyranosyl nucleotide subunits that are covalently linked between carbon 4 and carbon 2 of their respective pentopyranosyl rings. The pentopyranosyl nucleic acid also has an electrophilic reactive group. A biomolecule having a nucleophilic reactive group is also provided. The electrophilic reactive group of the pentopyranosyl nucleic acid and the nucleophilic reactive group of the biomolecule are reacted to form a covalent bond.Type: GrantFiled: February 20, 2009Date of Patent: August 17, 2010Assignee: Aventis Research & Technologies GmbH & Co.Inventors: Christian Miculka, Norbert Windhab, Tilmann Brandstetter, Gerhard Burdinski
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Patent number: 6822094Abstract: Spiro compounds of the formula (I), in which at least one of the radicals K1, L, M, N1, R1, R2, R3, R4 is one of the following groups are suitable as charge transport materials, in particular for photovoltaic cells, and as electroluminescence materials.Type: GrantFiled: July 26, 2002Date of Patent: November 23, 2004Assignee: Aventis Research & Technologies, GmbH & Co. KGInventors: Josef Salbeck, Donald Lupo
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Patent number: 6704086Abstract: The monostable ferroelectric active matrix display contains a liquid crystal layer in from of a monodomain with an unambiguously defined direction of the normal z to the layer of the smC* phase and is characterized by the fact that the normal z to the layer and the preferential direction n of the nematic or cholesteric phase (N* phase) form an angle of more than 5°.Type: GrantFiled: March 6, 2001Date of Patent: March 9, 2004Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Hans-Rolf Dübal, Rainer Wingen, Toshiaki Nonaka
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Patent number: 6661494Abstract: The monostable ferroelectric active matrix display comprises a liquid-crystal layer in the form of a monodomain having an unambiguously defined direction of the layer normal z of the smC* phase, the liquid-crystal layer preferably having a chevron C-1, chevron C-2 or bookshelf geometry.Type: GrantFiled: March 9, 2001Date of Patent: December 9, 2003Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Hans-Rolf Dübal, Rainer Wingen, Toshiaki Nonaka
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Patent number: 6646528Abstract: According to the inventive method for producing a superconductive coil, a shaped body consisting of a material which is superconductive or which becomes superconductive upon subsequent heat treatment is coated with reinforcement agents and is given the geometric shape of the future coil. The invention also relates to a superconductive coil produced according to this method. Said inventive superconductive coil has low alternating current loss and consists of a highly textured superconductive material, and is oriented in such a way that the platelet levels are directly considerably in the direction of the course of the coil. The coil is formed from a superconductive solid part.Type: GrantFiled: April 13, 2000Date of Patent: November 11, 2003Assignee: Aventis Research & TechnologiesInventors: Juergen Ehrenberg, Joachim Bock, Guenter Brommer
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Patent number: 6645568Abstract: The invention relates to a process for producing a coating having a titanium boride content of at least 80% by weight, in which a coating having a thickness of from 0.1 mm to 1 mm, a porosity of not more than 10% by volume and an oxygen content of less than 1% by weight is applied to the surface of a substrate by plasma spraying in an atmosphere which is virtually or completely free of oxygen, with no metallic powder being added to the spraying powder.Type: GrantFiled: December 6, 1999Date of Patent: November 11, 2003Assignee: Aventis Research & Technologies GmbH & Co KGInventors: Katharina Seitz, Stephan Süssbrich, Michael Hornung, Heinrich Kühn, Frank Hiltmann
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Publication number: 20030157505Abstract: The present invention relates to a substance library, to a process for the preparation thereof, to a process for the preparation of supramolecular complexes using this substance library and to the use of the supramolecular complexes prepared by means of the substance library, and to the use of the substance library itself.Type: ApplicationFiled: July 19, 2002Publication date: August 21, 2003Applicant: Aventis Research & Technologies Deutschland GmbH & Co. KGInventors: Christian Miculka, Norbert Windhab, Albert Eschenmoser, Gerhard Quinkert
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Patent number: 6605323Abstract: In a monostable ferroelectric active matrix display comprising a liquid-crystal layer in the form of a monodomain having an unambiguously defined direction of the layer normals z of the smC* phase, the layer normals z and the preferential direction n of the nematic or cholesteric phase (N* phase) form an angle of more than 5°.Type: GrantFiled: April 23, 2001Date of Patent: August 12, 2003Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Rainer Wingen, Barbara Hornung, Toshiaki Nonaka
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Patent number: 6589785Abstract: A method for disrupting frozen cells and/or tissue in a solid, frozen state in the presence of a solid denaturing substance is provided. The method comprises providing frozen cells and/or tissue in frozen solid form, adding thereto the solid denaturing substance in sold form, and applying mechanical force thereto for disruption of the frozen cells and/or tissue. The frozen cells and/or tissue include muscle cells and/or muscle tissue, wheat cells and/or wheat tissue, and maize cells and/or maize tissue. Further, the solid, denaturing substance in solid form is a crystalline substance and can be selected from urea, thiourea, guanidium chloride, guanidium thiocyanate and ammonium sulfate. Also the solid, denaturing substance in solid form is added to the frozen cells and/or tissue in frozen form in an approximately 1 to 20 fold (w/w) excess.Type: GrantFiled: July 31, 2000Date of Patent: July 8, 2003Assignee: Aventis Research & Technologies GmbH & Co KGInventors: Stefan Müllner, Thomas Neumann
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Patent number: 6582691Abstract: The invention relates to an insect cell vector for the production of proteins from the DEAD protein family.Type: GrantFiled: September 29, 2000Date of Patent: June 24, 2003Assignee: Aventis Research & Technologies GmbH & Co.Inventors: Karl-Christian Gallert, Stefan Müllner, Christoph Hüls, Britta Böhnisch
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Patent number: 6582916Abstract: Provided is a method for characterising an analyte, which method comprises: a) providing a compound in which the analyte is attached by at cleavable linker to a mass marker relatable to the analyte; b) cleaving the mass marker from the analyte; and c) identifying the mass marker, thereby characterising the analyte, wherein the mass marker comprises a metal ion-binding moiety.Type: GrantFiled: March 16, 2001Date of Patent: June 24, 2003Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Gunter Schmidt, Andrew Hugin Thompson, Robert Alexander W. Johnstone
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Patent number: 6579681Abstract: The present invention relates to a test system comprising (a) one or more identical or different immobilized nucleic acid(s) having at least one spliceable nucleic acid, (b) at least one gel-free detection system for detecting a splicing reaction, where appropriate (c) at least one composition comprising splicing components, and preferably (d) suitable detection probes, and, where appropriate, (e) further aids.Type: GrantFiled: November 27, 2001Date of Patent: June 17, 2003Assignee: Aventis Research and Technologies GmbH & Co. KGInventors: Christoph Hüls, Bettina Bauer, Claus Simandi, Reinhard Lührmann, Tilmann Achsel, Hans-Peter Vornlocher
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Patent number: 6576470Abstract: The invention pertains to a process for examining chemical reactions in the presence of potentially catalytical substances, wherein reactions are triggered in miniaturized reactors with volumes of 0.001 cm3 to 1 cm3 arranged parallel to each other, and the nature and amount of the reaction mixture are analyzed during the reaction time.Type: GrantFiled: November 22, 1999Date of Patent: June 10, 2003Assignee: Aventis Research & Technologies GmbH & Co KGInventors: Norbert Windhab, Christian Miculka, Hans-Ulrich Hoppe
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Patent number: 6551668Abstract: In a monostable ferroelectric active matrix display comprising a liquid-crystal layer in the form of a monodomain having an unambiguously defined direction of the layer normal z of the smC* phase, the layer normals z and the preferential direction n of the nematic or cholesteric phase (N* phase) form an angle of more than 5°.Type: GrantFiled: March 9, 2001Date of Patent: April 22, 2003Assignee: Aventis Research & TechnologiesInventors: Rainer Wingen, Barbara Hornung, Toshiaki Nonaka
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Patent number: 6549188Abstract: Ferroelectric liquid-crystal display having a broad operating temperature range. A ferroelectric liquid-crystal display containing a ferroelectric liquid-crystal mixture which is addressed with voltage pulses≧0.9 ms. The display according to the invention is particularly suitable for applications in which the length of the response time is not critical. Such displays can be operated with the same voltage over a broad temperature range; adjustment of the voltage as a function of temperature is not necessary. Examples of preferred applications are displays in chip cards, electronic price and display signs (shelf labels), PDAs (personal digital assistants) and pagers.Type: GrantFiled: June 15, 2000Date of Patent: April 15, 2003Assignee: Aventis Research & Technology Deutschland GmbH & Co.KGInventors: Ayako Takeichi, Barbara Hornung, Hans-Rolf Dübal
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Publication number: 20030039997Abstract: The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) 1Type: ApplicationFiled: May 16, 2002Publication date: February 27, 2003Applicant: Aventis Research and Technologies GmbH & Co. KGInventors: Christian Miculka, Norbert Windhab, Tilmann Brandstetter, Gerhard Burdinski
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Patent number: 6509507Abstract: A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second aromatic in a palladium-catalyzed cross-coupling reaction to give a biaryl and converting the ester or benzylic OH groups into polymerizable groups in one or more steps. The biaryls obtained are suitable for preparing polymers which are used as electroluminescence materials.Type: GrantFiled: October 16, 2001Date of Patent: January 21, 2003Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Hubert Spreitzer, Willi Kreuder, Heinrich Becker, Jochen Krause
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Patent number: 6485797Abstract: A ferroelectric liquid crystal mixture, especially useful for operation in the &tgr;Vmin−mode, comprises a 5-Arylindane derivative of the formula (I), wherein Y is CH, CF or N and R1(—A1—M1)a(—A2—M2)b—, (M3—A3—)cR2 are mesogenic groups.Type: GrantFiled: August 31, 2000Date of Patent: November 26, 2002Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Wolfgang Schmidt, Javier Manero, Barbara Hornung, Rainer Wingen, Ayako Ogawa
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Patent number: 6482478Abstract: Fluorinated derivatives of phenanthrene, and their use in liquid-crystal mixtures Fluorinated phenanthrene derivatives of the formula (I) in which G1 is —CH═CH— or —CH2CH2— X is H or F Y is H or F, and R1 and M1—A1—R2 are mesogenic radicals, are suitable as components of liquid-crystalline mixtures.Type: GrantFiled: September 5, 2000Date of Patent: November 19, 2002Assignee: Aventis Research & Technologies GmbH & Co. KGInventor: Rainer Wingen
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Patent number: 6451307Abstract: The present invention relates to a poly(A)-specific 3′-exonuclease activity which can be obtained by chromatographically purifying a crude extract of animal or human cells and to its use for deadenylating 3′-poly(A) tails of nucleic acids and as a pharmaceutical or diagnostic agent, or for identifying functional interactors.Type: GrantFiled: December 15, 2000Date of Patent: September 17, 2002Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Thomas Neumann, Christoph Hüls, Karl-Christian Gallert, Anders Virtanen, Jonas Aström, Javier Martinez, Ann-Charlotte Thuresson, Yanguo Ren