Patents Assigned to AVEO Pharmaceuticals, Inc.
  • ANTI-GDF15 ANTIBODIES
    Publication number: 20140193427
    Abstract: Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 10, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Lorena Lerner, Sandra Abbott, Ailin Bai, Ting Chen, Maria Isabel Chiu, Qing Liu, Laura Poling, Nianjun Tao, Solly Weiler, Zhigang Weng, William M. Winston, Jr., Jeno Gyuris
  • HEPATOCYTE GROWTH FACTOR (HGF) BINDING PROTEINS
    Publication number: 20140178935
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Application
    Filed: October 2, 2013
    Publication date: June 26, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: William M. Winston, JR., S. Kirk Wright, May Han, Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris, Arnold Horwitz
  • HEPATOCYTE GROWTH FACTOR (HGF) BINDING PROTEINS
    Publication number: 20140178934
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Application
    Filed: September 27, 2013
    Publication date: June 26, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: May Han, S. Kirk Wright, William M. Winston, JR., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris
  • ANTI-RON ANTIBODIES
    Publication number: 20140066603
    Abstract: Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
    Type: Application
    Filed: November 1, 2013
    Publication date: March 6, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Kerry Whalen, Steve Bottega, Andrea Boudrow, Lyne Breault, Ting Chen, James Gifford, May Han, Jinwei Jiang, Lorena Lerner, Qing Liu, Kristan Meetze, Sylvie Vincent, Solly Weiler, William M. Winston, Jr., Jeno Gyuris
  • TIVOZANIB RESPONSE PREDICTION
    Publication number: 20140045715
    Abstract: A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry.
    Type: Application
    Filed: August 5, 2013
    Publication date: February 13, 2014
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Jie Lin, Bin Feng, Murray Robinson, Feng Jiang, Xiaojian Sun
  • Anti-RON antibodies
    Patent number: 8603478
    Abstract: Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: December 10, 2013
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Kerry Whalen, Steve Bottega, Andrea Boudrow, Lyne Breault, Ting Chen, James Gifford, May Han, Jinwei Jiang, Lorena Lerner, Qing Liu, Kristan Meetze, Sylvie Vincent, Solly Weiler, William M. Winston, Jr., Jeno Gyuris
  • Hepatocyte growth factor (HGF) binding proteins
    Patent number: 8580930
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: November 12, 2013
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: William M. Winston, Jr., S. Kirk Wright, May Han, Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris, Arnold Horwitz
  • Hepatocyte growth factor (HGF) binding proteins
    Patent number: 8575318
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: November 5, 2013
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: May Han, S. Kirk Wright, William M. Winston, Jr., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris
  • Anti-FGFR2 antibodies
    Patent number: 8481688
    Abstract: Monoclonal antibodies that bind and inhibit biological activities of human FGFR2 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or overexpression of FGFR2.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: July 9, 2013
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Zhigang Weng, William M. Winston, Jr., Ailin Bai, Kristan Meetze, Solly Weiler, Ting Chen, Jeno Gyuris
  • Anti-ErbB3 antibodies
    Patent number: 8481687
    Abstract: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 9, 2013
    Assignee: Aveo Pharmaceuticals, Inc.
    Inventors: Sylvie Vincent, William M. Winston, Jr., Fang Wang, Solly Weiler, Kristan Meetze, Lyne Breault, Steve Bottega, Ting Chen, Michael DePrima, Christina Fleet, Steven Tyler, Jin-Kyeung Woo, Jeno Gyuris
  • IDENTIFICATION OF MULTIGENE BIOMARKERS
    Publication number: 20130165337
    Abstract: Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein.
    Type: Application
    Filed: November 5, 2012
    Publication date: June 27, 2013
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventor: AVEO PHARMACEUTICALS, INC.
  • IDENTIFICATION OF MULTIGENE BIOMARKERS
    Publication number: 20130165343
    Abstract: Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein.
    Type: Application
    Filed: February 25, 2013
    Publication date: June 27, 2013
    Applicant: AVEO Pharmaceuticals, Inc.
    Inventor: AVEO Pharmaceuticals, Inc.
  • Reconstituted human breast tumor model
    Patent number: 8373017
    Abstract: Reconstituted human breast tumor models are disclosed. The models, which are incorporated into mice, provide actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain either: (a) a recombinant human oncogene and an SV40er; or (b) a recombinant human oncogene, a transgene or shRNA that inhibits the p53 pathway, and a transgene or shRNA that inhibits the Rb pathway.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 12, 2013
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Min Wu, Charlotte Kuperwasser, Murray Robinson
  • USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSTICS, AND TREATMENT
    Publication number: 20120302572
    Abstract: The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods.
    Type: Application
    Filed: April 25, 2012
    Publication date: November 29, 2012
    Applicants: AVEO PHARMACEUTICALS, INC., OSI Pharmaceuticals, LLC
    Inventors: Julie Kan, Stuart Thomson, Gretchen M. Argast, Matthew E. O'Connor, Murray Robinson, Bin Feng, Joerg Heyer, Maria I. Chiu, Richard Nicoletti
  • Hepatocyte growth factor (HGF) binding proteins
    Patent number: 8273355
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 25, 2012
    Assignees: AVEO Pharmaceuticals, Inc., XOMA Technology Ltd.
    Inventors: William M. Winston, Jr., S. Kirk Wright, May Han, Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris, Arnold Horwitz
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    Patent number: 8268315
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 18, 2012
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: May Han, S. Kirk Wright, William M. Winston, Jr., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris
  • Fibroblast growth factor receptor 3 (FGFR3) binding proteins
    Patent number: 8187601
    Abstract: Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: May 29, 2012
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Zhigang Weng, William M. Winston, Jr., Lyne Breault, Kristan Meetze, Solly Weiler, Jeno Gyuris
  • Tivozanib and temsirolimus in combination
    Patent number: 7998973
    Abstract: A method of treating a tumor in a human patient is disclosed. The method comprises co-administering to the patient: (a) a dose of 1.5 mg tivozanib per day; and (b) a dose of 25 mg temsirolimus per week. In some embodiments of the invention, the tivozanib is administered on a repeating schedule of one dose per day for three weeks, followed by one week without tivozanib administration. The disclosed method is particularly suitable for treatment of renal cell carcinoma.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: August 16, 2011
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Pankaj Bhargava, W. Brooke Esteves, John L. Ryan
  • Hepatocyte growth factor (HGF) binding proteins
    Patent number: 7943344
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: May 17, 2011
    Assignees: AVEO Pharmaceuticals, Inc., XOMA Technology Ltd.
    Inventors: William M. Winston, Jr., S. Kirk Wright, May Han, Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris, Arnold Horwitz
  • Hepatocyte growth factor (HGF) binding proteins
    Patent number: 7935502
    Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: May 3, 2011
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: May Han, S. Kirk Wright, William M. Winston, Jr., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris