Abstract: The disclosure relates to systems and devices for diagnosing infectious disease (e.g., bacterial or viral infections). More particularly, the disclosure relates to acoustic sensors for detecting infectious disease caused by viral infections (e.g., coronavirus, rhinovirus, influenza, etc.).

Abstract: A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) biosensor based system for point-of-care diagnostics. The SAW biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.

Abstract: Various liquid cells for use in surface acoustic wave-based sensors are disclosed. The sensor can include a substrate, at least one sensor element, and at least one pair of electrical components. The electrical components can be located on opposite ends of the sensor element. The liquid cell can include a top layer that is configured to cover at least a portion of the pair of electrical components. The liquid cell can also include a fluidic channel. The fluidic channel can be configured to receive a liquid media and is arranged not intersect with any of the pair of electrical components. The liquid cell can also include a plurality of peripheral walls that are configured to form a plurality of air pockets. Each of the plurality of air pockets are configured to form virtual non-physical walls to prevent the liquid media from contacting the at least one sensor element.

Abstract: Various liquid cells for use in surface acoustic wave-based sensors are disclosed. The sensor can include a substrate, at least one sensor element, and at least one pair of electrical components. The electrical components can be located on opposite ends of the sensor element. The liquid cell can include a top layer that is configured to cover at least a portion of the pair of electrical components. The liquid cell can also include a fluidic channel. The fluidic channel can be configured to receive a liquid media and is arranged not intersect with any of the pair of electrical components. The liquid cell can also include a plurality of peripheral walls that are configured to form a plurality of air pockets. Each of the plurality of air pockets are configured to form virtual non-physical walls to prevent the liquid media from contacting the at least one sensor element.

Abstract: A multiplexing surface acoustic wave (SAW) device for simultaneous excitation of SAW sensors or simultaneous sensing of multiple analytes, targets or bio-agents. The device includes a plurality of SAW sensors arranged in an array. Each sensor has a delay line and each of the delay lines are different in length. The sensors of the multiplexing SAW device are excited simultaneously to generate an array of surface acoustic waves propagating along the delay lines of each SAW sensor. Because the length of each delay line is different for each SAW sensor, the propagation time of the surface acoustic waves varies in based at least in part on the length variation. A compressed pulse train can be generated with a specific time delay according to the length difference of delay lines. Phase or other information of the compressed pulse can be extracted.

Abstract: An acoustic wave biosensor component is provided. The acoustic wave biosensor comprising a piezoelectric substrate with or without 3D matrix microstructure to increase the surface of the effective sensing area and an anchor substance covalently bound to a surface of the piezoelectric substrate, and the anchor substance can bind to a capture reagent. A process for fabricating the 3D biosensor surface and component coating the surface of a piezoelectric material with bioactive film comprising an anchor substance is also provided.

Abstract: An acoustic wave biosensor component is provided. A method of amplifying the biosensor signal is also provided, including applying a polymer or metallic material to the analyte after the analyte is attached to the capture agent on the biosensor.

Abstract: Biosensor components (chips) are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezo-electrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table mono layers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biot-inylated antibody for capture and detection of analytes in biologic fluid samples.

Abstract: Biosensor components (chips) are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezo-electrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table mono layers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biot-inylated antibody for capture and detection of analytes in biologic fluid samples.