Abstract: Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient using dual or multiple radiopharmaceutical probes are provided herein.
Type:
Application
Filed:
October 14, 2013
Publication date:
February 13, 2014
Applicant:
Avid Radiopharmaceuticals, Inc.
Inventors:
Franz F. Hefti, Daniel M. Skovronsky, Alan P. Carpenter
Abstract: This invention relates to a method of imaging vesicular monoamine transporters and to labeled compounds and pharmaceutical compositions thereof, and methods of making labeled compounds useful in imaging vesicular monoamine transporters. This invention also relates to compounds, and methods of monitoring progression of a disease related to vesicular monoamine transporters.
Type:
Grant
Filed:
May 2, 2007
Date of Patent:
October 22, 2013
Assignees:
The Trustees of the University of Pennsylvania, The Regents of the University of Michigan, Avid Radiopharmaceuticals, Inc.
Inventors:
Hank F. Kung, Mei-Ping Kung, Michael Kilbourn, Daniel M. Skovronsky
Abstract: Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient using dual or multiple radiopharmaceutical probes are provided herein.
Type:
Grant
Filed:
April 3, 2009
Date of Patent:
October 15, 2013
Assignee:
Avid Radiopharmaceuticals, Inc.
Inventors:
Franz F. Hefti, Daniel M. Skovronsky, Alan P. Carpenter, Jr.
Abstract: The present invention relates to a method of detecting ?-amyloid peptide aggregates in the brain of an individual and kits thereto. The method includes administering to an individual an effective amount of an A?-binding radiopharmaceutical, waiting a period of time, measuring a gamma radiation count over an external area of the head corresponding to the cortex of the individual using a radiation detection device, and comparing the gamma radiation count with a control gamma radiation count.
Abstract: The present invention relates to methods of synthesizing 18F-radiolabeled styrylpyridine and its tosylate precursor. The present invention further relates to stable pharmaceutical compositions comprising 18F-radiolabeled styrylpyridine.
Abstract: An analysis method using histograms derived from positron emission tomography (PET) or single photon emission tomography (SPECT) images of the brain, which utilizes radiopharmaceuticals for the detection and diagnosis of pathological targets associated with neurodegenerative disease in a patient is provided.
Type:
Application
Filed:
November 12, 2009
Publication date:
June 10, 2010
Applicant:
AVID RADIOPHARMACEUTICALS, INC.
Inventors:
Abhinay D. Joshi, John G. Wolodzko, Krishnendu Saha
Abstract: Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient using dual or multiple radiopharmaceutical probes are provided herein.
Type:
Application
Filed:
April 3, 2009
Publication date:
October 15, 2009
Applicant:
AVID RADIOPHARMACEUTICALS, INC.
Inventors:
Franz F. Hefti, Daniel M. Skovronsky, Alan P. Carpenter, JR.