Abstract: This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR) and in concert with the TR for directional, site-specific diversification. Further provided are methods of preparing and using these nucleic acid sequences.
Type:
Grant
Filed:
August 3, 2005
Date of Patent:
September 8, 2009
Assignees:
The Regents of the University of California, AvidBiotics Corp
Inventors:
Jeffery F. Miller, Sergei Doulatov, Asher Hodes, Min Xu, Mari Gingery, David W. Martin, Jr.