Patents Assigned to AvidBiotics Corporation
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Patent number: 8673553Abstract: Recombinant P4 bacteriophage containing modified tail fibers having a base plate attachment region (BPAR) from a P2 bacteriophage gene H product and a heterologous receptor binding domain (RBD) are disclosed. Methods for the use of the recombinant P4 bacteriophage, such as to detect the presence of a target bacterium in a sample, are also described.Type: GrantFiled: March 12, 2013Date of Patent: March 18, 2014Assignee: AvidBiotics CorporationInventors: Dean M. Scholl, Steven R. Williams
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Publication number: 20130184183Abstract: Recombinant P4 bacteriophage containing modified tail fibers having a base plate attachment region (BPAR) from a P2 bacteriophage gene H product and a heterologous receptor binding domain (RBD) are disclosed. Methods for the use of the recombinant P4 bacteriophage, such as to detect the presence of a target bacterium in a sample, are also described.Type: ApplicationFiled: March 12, 2013Publication date: July 18, 2013Applicant: AvidBiotics CorporationInventor: AvidBiotics Corporation
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Patent number: 8445639Abstract: Recombinant P4 bacteriophage containing modified tail fibers having a base plate attachment region (BPAR) from a P2 bacteriophage gene H product and a heterologous receptor binding domain (RBD) are disclosed. Methods for the use of the recombinant P4 bacteriophage, such as to detect the presence of a target bacterium in a sample, are also described.Type: GrantFiled: November 8, 2010Date of Patent: May 21, 2013Assignee: AvidBiotics CorporationInventors: Dean Scholl, Steven Williams
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Patent number: 8206971Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: GrantFiled: February 5, 2010Date of Patent: June 26, 2012Assignee: AvidBiotics CorporationInventors: Dean M. Scholl, Steven R. Williams
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Publication number: 20110183893Abstract: This invention describes soluble, monovalent, non-natural protein molecules that can activate NK cells and certain T-cells to attack specific cellular target cells by attaching the NKG2D-binding portions of monovalent MICA or MICB protein, i.e. their ?1-?2 platform domain, to the intended target cell specifically. The ?1-?2 domain is contiguous with a heterologous ?3 domain that has been genetically modified to bind directly or indirectly to the extracellular aspect of the target cell, thereby serving as the targeting domain. The genetic modification to create a non-natural and non-terminal targeting motif within the ?3 domain can include a portion of an antibody, another protein molecule or portion thereof, a peptide, or a non-natural, modified ?3 domain of a MIC protein.Type: ApplicationFiled: December 30, 2010Publication date: July 28, 2011Applicant: AvidBiotics CorporationInventors: David W. MARTIN, JR., Steven R. Williams
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Publication number: 20110136688Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: ApplicationFiled: November 8, 2010Publication date: June 9, 2011Applicant: AvidBiotics CorporationInventors: Dean SCHOLL, Steven Williams
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Publication number: 20100261258Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: ApplicationFiled: February 5, 2010Publication date: October 14, 2010Applicant: AvidBiotics CorporationInventors: Dean M. Scholl, Steven R. Williams
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Patent number: 7732586Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: GrantFiled: May 14, 2007Date of Patent: June 8, 2010Assignee: AvidBiotics CorporationInventors: David W. Martin, Jr., Andrew C. Jamieson, Dean M. Scholl, Steven R. Williams
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Patent number: 7700729Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: GrantFiled: October 30, 2007Date of Patent: April 20, 2010Assignee: AvidBiotics CorporationInventors: Dean M. Scholl, Steven R. Williams
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Publication number: 20080286236Abstract: The disclosure relates to the targeting of Y. pestis mediated by the binding activity of tail fibers from naturally occurring R-type pyocins from Pseudomonas aeruginosa. The targeting may be mediated by a macromolecular complex such as the pyocin itself, a high molecular weight (hmw) bacteriocin modified to have the tail fiber's binding activity, or a bacteriophage modified to have the tail fiber's binding activity. Compositions comprising such complexes are described. Also disclosed are methods for the use of a complex, such as to inhibit the growth of a Yersinia species like Y. pestis, by compromising the integrity of its cytoplasmic membrane are also described. Additional methods include use of the binding activity to identify Y. pestis.Type: ApplicationFiled: May 14, 2007Publication date: November 20, 2008Applicant: AvidBiotics CorporationInventors: Dana M. Gebhart, Dean M. Scholl
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Publication number: 20080171376Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: ApplicationFiled: October 30, 2007Publication date: July 17, 2008Applicant: AvidBiotics CorporationInventors: Dean M. SCHOLL, Steven R. WILLIAMS
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Publication number: 20080113406Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.Type: ApplicationFiled: May 14, 2007Publication date: May 15, 2008Applicant: AvidBiotics CorporationInventors: David W. Martin, Andrew C. Jamieson, Dean M. Scholl, Steven R. Williams
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Publication number: 20060121450Abstract: This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR) and in concert with the TR for directional, site-specific diversification. Further provided are methods of preparing and using these nucleic acid sequences.Type: ApplicationFiled: August 3, 2005Publication date: June 8, 2006Applicants: The Regents of the University of California, AvidBiotics CorporationInventors: Jeffery Miller, Sergei Doulatov, Asher Hodes, Min Xu, Mari Gingery, David Martin