Patents Assigned to Avigen, Inc.
  • Publication number: 20100035920
    Abstract: The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.
    Type: Application
    Filed: August 31, 2009
    Publication date: February 11, 2010
    Applicant: Avigen, Inc.
    Inventors: Federico C.A. Gaeta, Matthew Gross, Kirk W. Johnson
  • Patent number: 7622256
    Abstract: Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and behavioral addictions, as well as for treating neuropathic pain.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: November 24, 2009
    Assignee: Avigen, Inc.
    Inventors: Kirk W. Johnson, Sharmila Vijay, Matthew Gross, Federico C. A. Gaeta
  • Publication number: 20090253743
    Abstract: The present disclosure is directed to methods for providing tolperisone having extremely low levels of 4-MMPPO (2-methyl-1-(4-methylphenyl)-propenone), as well as related compositions. The invention further relates to methods of treating a subject with tolperisone under conditions that limit exposure of the subject to tolerable levels of 4-MMPPO, among other features.
    Type: Application
    Filed: November 26, 2008
    Publication date: October 8, 2009
    Applicants: Avigen, Inc., Sanochemia Pharmazeutika, AG
    Inventors: Federico Gaeta, Stefan Welzig, Jan Rothenburger, Beate Kalz, Jozsef Gungl, Klaus Gerdes
  • Patent number: 7585875
    Abstract: The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: September 8, 2009
    Assignee: Avigen, Inc.
    Inventors: Federico C. A. Gaeta, Matthew Gross, Kirk W. Johnson
  • Patent number: 7534806
    Abstract: The present invention is directed to the use of ibudilast for treating neuropathic pain.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: May 19, 2009
    Assignee: Avigen, Inc.
    Inventors: Kirk W. Johnson, Lance Sultzbaugh, Jennifer Shumilla
  • Publication number: 20090098185
    Abstract: Methods for treating thrombotic disorders using sulfated polysaccharides such as fucoidans are disclosed.
    Type: Application
    Filed: December 15, 2008
    Publication date: April 16, 2009
    Applicant: AVIGEN, INC.
    Inventor: Kirk W. Johnson
  • Patent number: 7507873
    Abstract: Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: March 24, 2009
    Assignee: AviGenics, Inc.
    Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
  • Patent number: 7445774
    Abstract: This invention provides for human interferon-? which includes novel glycosylation structures.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: November 4, 2008
    Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Patent number: 7381712
    Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 3, 2008
    Assignee: AviGenics, Inc.
    Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn M. Matthews
  • Patent number: 7375258
    Abstract: The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: May 20, 2008
    Assignee: AviGenics, Inc.
    Inventors: Alex J. Harvey, Youliang Wang
  • Patent number: 7351582
    Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: April 1, 2008
    Assignee: AviGenics, Inc.
    Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
  • Publication number: 20080070912
    Abstract: The present invention is directed to substituted pyrazolo[1,5-?]pyridines and related methods for their synthesis and use.
    Type: Application
    Filed: June 6, 2007
    Publication date: March 20, 2008
    Applicant: Avigen, Inc.
    Inventors: Federico Gaeta, Matthew Gross, Kirk Johnson
  • Patent number: 7339090
    Abstract: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: March 4, 2008
    Assignee: AviGenics, Inc.
    Inventor: Leandro Christmann
  • Patent number: 7338654
    Abstract: This invention includes compositions comprising glycosylated human interferon-? derived from a chicken.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: March 4, 2008
    Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Patent number: 7335761
    Abstract: The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: February 26, 2008
    Assignee: AviGenics, Inc.
    Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
  • Patent number: 7312374
    Abstract: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: December 25, 2007
    Assignee: AviGenics, Inc
    Inventors: Jeffrey C. Rapp, Leandro Christmann
  • Patent number: 7294507
    Abstract: The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: November 13, 2007
    Assignee: AviGenics, Inc.
    Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
  • Patent number: 7199279
    Abstract: The invention provides for cells containing nucleic acids which include lysozyme gene expression controlling region nucleotide sequences which typically are linked to a polynucleotide encoding a heterologous polypeptide.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: April 3, 2007
    Assignee: AviGenics, Inc.
    Inventor: Jeffrey C. Rapp
  • Patent number: 7176300
    Abstract: The invention provides for lysozyme gene expression control regions which may include a 5? matrix attachment region; an intrinsically curved region of DNA; a transcription enhancer; a negative regulatory element; at least one hormone responsive element; an avian CRI repeat element; a proximal lysozyme promoter, and can be linked to a nucleotide sequence encoding a heterologous polypeptide.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: February 13, 2007
    Assignee: AviGenics, Inc.
    Inventor: Jeffrey C. Rapp
  • Patent number: 7129390
    Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: October 31, 2006
    Assignees: AviGenics, Inc, University of Georgia Research Foundation, Inc.
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp