Patents Assigned to Avila Therapeutics, Inc.
  • HCV protease inhibitors and uses thereof
    Patent number: 8293705
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: October 23, 2012
    Assignee: Avila Therapeutics, Inc.
    Inventors: Deqiang Niu, Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Lixin Qiao
  • PI3 KINASE INHIBITORS AND USES THEREOF
    Publication number: 20120258967
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 8, 2012
    Publication date: October 11, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Lixin Qiao, Deqiang Niu, Russell C. Petter, Zhengdong Zhu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20120238593
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 31, 2012
    Publication date: September 20, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter
  • Heterocyclic compounds and uses thereof
    Patent number: 8242271
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: August 14, 2012
    Assignee: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20120190614
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 10, 2012
    Publication date: July 26, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Deqiang Niu, Russell C. Petter, Lixin Qiao, Juswinder Singh
  • MUTANT-SELECTIVE EGFR INHIBITORS AND USES THEREOF
    Publication number: 20120157426
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 8, 2011
    Publication date: June 21, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Kwangho Lee, Deqiang Niu, Matthew F. Baevsky
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20120149687
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 31, 2011
    Publication date: June 14, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Kwangho Lee, Deqiang Niu, Russell C. Petter, Matthew F. Baevsky, Juswinder Singh
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20120149722
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 31, 2011
    Publication date: June 14, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Kwangho Lee, Deqiang Niu, Russell C. Petter, Juswinder Singh
  • HCV protease inhibitors and uses thereof
    Patent number: 8188137
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: May 29, 2012
    Assignee: Avila Therapeutics, Inc.
    Inventors: Deqiang Niu, Russell C. Petter, Lixin Qiao, Juswinder Singh
  • BESYLATE SALT OF A BTK INHIBITOR
    Publication number: 20120077832
    Abstract: The present invention provides a salt form, and compositions thereof, useful as an inhibitor of one or more protein kinases and which exhibits desirable characteristics for the same.
    Type: Application
    Filed: August 8, 2011
    Publication date: March 29, 2012
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Steven Richard Witowski, William Frederick Westlin, III, Richland Wayne Tester
  • PI3 KINASE INHIBITORS AND USES THEREOF
    Publication number: 20110230476
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 22, 2011
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: DEQIANG NIU, RUSSELL C. PETTER, JUSWINDER SINGH, ARTHUR F. KLUGE, HORMOZ MAZDIYASNI, ZHENDONG ZHU, LIXIN QIAO, KEVIN KUNTZ
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20110230494
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 1, 2011
    Publication date: September 22, 2011
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20110224432
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 1, 2011
    Publication date: September 15, 2011
    Applicant: AVILA THERAPEUTICS, INC.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • 4,6-disubstituted pyrimidines useful as kinase inhibitors
    Patent number: 7989465
    Abstract: The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable salts and compositions thereof, and methods of using the same. The present invention also provides probe compounds, such as compounds of formula V: wherein each of Ring A, Ring B, R1?, T, Rt, m, Rx, Ry, and W is described herein.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: August 2, 2011
    Assignee: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • 4,6-disubstitued pyrimidines useful as kinase inhibitors
    Patent number: 7982036
    Abstract: The present invention provides compounds of formula I wherein Ring A, Ring B, m, Rx, Ry, W and R1 are as defined herein, pharmaceutically acceptable salts and compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: July 19, 2011
    Assignee: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • Protein Kinase Conjugates and Inhibitors
    Publication number: 20110117073
    Abstract: The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
    Type: Application
    Filed: September 15, 2010
    Publication date: May 19, 2011
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Colyn Petter, Deqiang Niu, Lixin Qiao, Arthur Kluge, Roy Lobb, Shomir Ghosh, Zhendong Zhu
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20100249092
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 29, 2009
    Publication date: September 30, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Petter, Richland Wayne Tester, Arthur F. Kluge, Hormoz Mazdiyasni, William Frederick Westlin, III, Deqiang Niu, Lixin Qiao
  • ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS
    Publication number: 20100185419
    Abstract: The invention is an algorithm and method for designing an inhibitor that covalently binds a target polypeptide. The algorithm and method can be used to rapidly and efficiently convert reversible inhibitors into irreversible inhibitors.
    Type: Application
    Filed: September 4, 2009
    Publication date: July 22, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Colyn Petter, Dequiang Niu
  • METHODS FOR IDENTIFYING HCV PROTEASE INHIBITORS
    Publication number: 20100074890
    Abstract: The present invention provides methods for identifying compounds useful as HCV protease inhibitors.
    Type: Application
    Filed: September 18, 2009
    Publication date: March 25, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Margit Hagel, Thia B. St. Martin, Mariana S. Nacht
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20100069294
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 2, 2009
    Publication date: March 18, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Deqiang Niu, Lixin Qiao, Shomir Ghosh