Abstract: The present invention relates to a bird in which human immunoglobulin G (hIgG) Fc, a protein fused with a human-derived protein and Fc, or a monoclonal antibody is expressed in a hepatocyte-specific manner, and a method for producing the same. Birds produced by the production method of the present invention can economically mass-produce human immunoglobulin Fc with enhanced anti-inflammatory effects in egg yolk and blood.