Abstract: The present invention provides a method for producing pH-stable enveloped viruses wherein said viruses are used for infection of host cells under low pH conditions and for incubation with cell culture cells under conditions of low pH, as well as influenza viruses obtainable by this method which exhibit a high growth rate in cell culture, increased pH and temperature stability and which have human receptor specificity.
Type:
Application
Filed:
November 25, 2009
Publication date:
July 8, 2010
Applicant:
AVIR Green Hills Biotechnology Research Developmen Trade AG
Inventors:
Brigitte KRENN, Markus WOLSCHEK, Julia ROMANOVA, Andrej EGOROV, Sabine Nakowitsch
Abstract: The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies.
Type:
Application
Filed:
May 23, 2008
Publication date:
June 3, 2010
Applicant:
AVIR GREEN HILLS BIOTECHNOLOGY RESEARCH DEVELOPMEN
Inventors:
Johannes Humer, Bernd Mayer, Thomas Muster, Andrea Waltenberger