Patents Assigned to Avitech Diagnostics, Inc.
  • Detection of mutation by resolvase cleavage
    Patent number: 5698400
    Abstract: Methods are disclosed for detecting one or more mutations in an isolated test nucleic acid by forming a heteroduplex with a homologous control DNA and contacting the heteroduplex with a resolvase capable of recognizing at least one single base pair mismatch within the heteroduplex. In preferred embodiments of the invention, the resolvase is bacteriophage T4 endonuclease VII.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: December 16, 1997
    Assignee: Avitech Diagnostics, Inc.
    Inventors: Richard G. H. Cotton, Rima Youil, Borries W. Kemper