Abstract: Starting from two non-miscible phases, i.e., a lipophilic and a hydrophilic phase, a surface-active substance and a recognition component, a micellar recognition system is built in a suitable manner and is incorporated into a layer structure. The micellar recognition system is provided in a single thin layer in which the recognition component is distributed homogeneously. Additional layers which may be provided about this layer, have an influence on the properties of the entire layer structure. On contact between the layer structure and the substance to be measured a recognition step takes place in the layer which is followed by a transducing step. In this way a measurement variable is produced by means of which information is obtained on the substance. The layer structures exhibit higher sensitivity, a lower detection threshold, short response time and special robustness with regard to sample interference.

Abstract: A control or calibration standard for use with instruments for the optical measurement of the hemoglobin content in blood samples, features scattering particles or beads dispersed in aqueous electrolyte solution. To prevent sedimentation of the beads during storage, they have a mean diameter of <0.6 &mgr;m, preferably about 0.3 &mgr;m, and a volume concentration of <1%, preferably <0.3%. To prevent long term agglomeration, a non-ionic surfactant with an added antioxidant can be included in the formulation.

Abstract: The sensor membrane of an optical sensor for detection of O.sub.2, H.sub.2 O.sub.2, SO.sub.2 or halogenated hydrocarbons in a sample contains an indicator substance that is homogeneously immobilized in the polymer matrix of the sensor membrane and is, at least indirectly, in contact with the sample, changing at least one of its optical properties upon a change of the parameter to be measured. The indicator substance contains an inorganic salt of a transition metal complex with .alpha.-diimine ligands. The indicator substance is homogeneously distributed in the polymer matrix, which essentially consists of at least one substance belonging to the group of cellulose derivatives, polystyrenes, polytetrahydrofuranes, or their respective derivatives.

Abstract: In a method of optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, using at least two wavelengths for measuring, a first wavelength of .lambda.<805 nm and a second wavelength of .lambda.>805 nm is employed, such that the following is valid for the absorption coefficients of the hemoglobin derivatives O.sub.2 Hb and RHb at the two measurement wavelengths .lambda..sub.1 and .lambda..sub.2 : .sigma.O(.lambda..sub.1).about..sigma.R(.lambda..sub.2) and .sigma.R(.lambda..sub.1).about..sigma.O(.lambda..sub.2). The sum of absorption values A.sub.1 and A.sub.2 measured at wavelengths .lambda..sub.1 and .lambda..sub.2 will be a quantity which is proportional to the total hemoglobin concentration tHb and independent of the oxygen saturation O.sub.2sat.

Abstract: A device for withdrawing a liquid from a sealed glass ampoule includes a frame holding the sealed glass ampoule in upright or slightly inclined position, such that a tip of the ampoule points upwardly. An element is provided which will press or knock against the side of the tip or neck of the ampoule in order to break the tip of the ampoule in the region of the neck. The device further includes a withdrawing element which can be introduced into the glass ampoule in an area between the bottom of the ampoule and the surface of the liquid therein, and which includes a cannula for withdrawing the liquid.

Abstract: In a gas mixing system for producing high-precision, continuous streams of mixed gas consisting of a plurality of individually metered gas components, with an individual gas line including a pressure reducing element and, if desired, a precision pressure regulator for each gas component, precision is further improved by providing that each gas line lead to a separate valve which is timed by electronic control means, the valves being connected at the input side via a jointly vented system of lines for pressure equalization, and communicating at the output side via a mixed gas line with a mixing chamber downstream thereof.

Abstract: In a sensor layer for quantitative determination of at least one chemical component in a gaseous or liquid sample medium containing a chromophore which is directly or indirectly responsive to the component being determined by changing its absorption spectrum, and a luminophore which is not responsive to the component being determined, where there is an at least partial overlap between the emission spectrum of the luminophore and the absorption spectrum of the chromophore, and where the energy transfer between luminophore and chromophore produces a measurable change in at least one luminescence characteristic of the luminophore, the luminophore L and the chromophore .GAMMA. are ionic substances with differing electrical charges, which are incorporated in a matrix material that is permeable to the chemical component being determined.

Abstract: For the purpose of determining the concentration c of an absorbing medium distributed homogeneously in a carrier, even if the film thickness d of the carrier is unknown, an absorbing medium is used whose measured absorption a(.lambda.) deviates from Lambert-Beer's law, in particular in the region of higher concentration, and n.gtoreq.2 model components of the absorbing medium are assumed, so thata(.lambda.)=(.epsilon..sub.1 (.lambda.).c.sub.1 +.epsilon..sub.2 (.lambda.).c.sub.2 + . . . .epsilon..sub.n (.lambda.).c.sub.n).d.The absorption a(.lambda..sub.i) is measured for at least n wavelengths, and the spectral absorption values .epsilon..sub.i (.lambda..sub.i) and concentrations c.sub.i of the model components are computed and the concentration c is determined from the functional relationship between the concentration c and concentrations c.sub.i of the model components c=f(c.sub.i), which relationship is obtained by calibrating measurements.

Abstract: Quality control of an analyzing system that includes a portable analyzer with insertable single-use cartridges whose sample chamber contains optical and/or electrochemical sensors is accomplished by bringing the sensors in the single-use cartridge into contact, or are in contact with, a calibrating and/or conditioning medium, the calibrating and/or conditioning medium exhibiting chemical and/or physical parameters which influence the characteristic of at least one of the sensors. Just before a sample is measured, the sensors are contacted with a quality control liquid which is identical with the calibrating and/or conditioning medium within a predetermined desired range of accuracy for the sample components to be measured, as regards the chemical and/or physical parameters influencing the characteristic of at least one sensor during calibration and/or conditioning. The instantaneous control values obtained on the basis of the calibration values are subsequently compared to known target control values.

Abstract: A device for performing electrochemical and/or optical measurements in fluids, includes a sensor part of substantially planar configuration carrying a plurality of sensors that are connected to conductive paths; a cover part, which includes a groove-shaped measuring channel through which the fluid will flow; and a sealing element positioned between the sensor part and the cover part for sealing the measuring channel. The cover part includes grooves which extend in parallel with the measuring channel and which define respective ridges between the grooves and the measuring channel, and the sealing element substantially includes guiding bodies which are retained in the grooves of the cover part and are provided with integrally molded narrow sealing lips protruding in the area of the ridge. The sensor part and the cover part are joined by a plurality of locking elements which are distributed along the measuring channel.

Abstract: In a glass ampoule for holding a drug, a calibration liquid or a quality control liquid, whose bottom is flat or recessed towards the interior of the ampoule, the bottom area is shaped and/or coated such that a predefined breaking site is provided, which can be mechanically destroyed with little use of force.

Abstract: In a sensor layer for quantitative determination of at least one chemical component in a gaseous or liquid sample medium containing a chromophore which is directly or indirectly responsive to the component being determined by changing its absorption spectrum, and a luminophore which is not responsive to the component being determined, where there is an at least partial overlap between the emission spectrum of the luminophore and the absorption spectrum of the chromophore, and where the energy transfer between luminophore and chromophore produces a measurable change in at least one luminescence characteristic of the luminophore, the luminophore L and the chromophore .GAMMA. are ionic substances with differing electrical charges, which are incorporated in a matrix material that is permeable to the chemical component being determined.

Abstract: Biological components such as enzymes are immobilized in a three-dimensional cross-linked hydrophobic polymer. An enzyme is mixed with an aqueous solvent and a non-crosslinked prepolymer having an essentially nonpolar main chain with attached polar hydrophilic groups and cross-linking groups. The resultant mixture is exposed to cross-linking temperatures to react the prepolymer via the cross-linking groups without additional catalyst or cross-linking agents, and the aqueous solvent is evaporated to form a three-dimensional cross-linked hydrophobic polymer matrix containing the enzyme. The prepolymer can be an oil alkyl resin containing the main chain with attached polar hydrophilic groups and cross-linking groups. The oil alkyl resin is cross-linked by autoxidation, and aqueous solvent is evaporated to form the polymer matrix.

Abstract: Starting from two non-miscible phases, i.e., a lipophilic and a hydrophilic phase, a surface-active substance and a recognition component, a micellar recognition system is built in a suitable manner and is incorporated into a layer structure. The micellar recognition system is provided in a single thin layer in which the recognition component is distributed homogeneously. Additional layers which may be provided about this layer, have an influence on the properties of the entire layer structure. On contact between the layer structure and the substance to be measured a recognition step takes place in the layer which is followed by a transducing step. In this way a measurement variable is produced by means of which information is obtained on the substance. The layer structures exhibit higher sensitivity, a lower detection threshold, short response time and special robustness with regard to sample interference.

Abstract: An apparatus for determining the concentrations of n hemoglobin derivatives in a sample of undiluted, unhemolyzed whole blood provided in a cuvette, employs a device producing a primary light beam formed of at least n substantially monochromatic, narrow-band components of different wavelengths. Further provided is a detection device for measuring of the radiation passing through the cuvette. At least two measuring geometries are provided for spectral detection of a collimated central beam and at least one scatter beam, and detection of the central beam departing from a first measuring location in the cuvette takes place in a first measuring position on the axis of the primary beam, and detection of the scatter beam takes place in a second measuring position if it departs from the first measuring location in the cuvette, or in the first measuring position if it departs from a second measuring location in the cuvette, whereby the axes of the central beam and the scatter beam(s) enclose angles .alpha..sub.

Abstract: An optochemical fluorescence sensor with a biorecognitive layer for measuring the concentration of one or more analytes in a sample is provided with at least one island layer which is applied on a sensor substrate. The islands of the island layer are in the form of electrically-conductive material and have a diameter of less than 300 nm, the biorecognitive layer being directly applied on the island layer or bound via a spacer film. In addition, an analyte-specific fluorescent compound is provided which may be added to the sample or is provided in the sensor itself. The biorecognitive layer can bind the analyte to be measured directly or by means of analyte-binding molecules, the originally low quantum yield of the fluorescent compound increasing strongly in the vicinity of the island layer.

Abstract: A measuring assembly comprises a supporting element transparent to excitation and measurement radiation, which is provided with a number of preferably different luminescence-optical sensor elements on a first boundary face. Via a second boundary face excitation radiation can be picked up, and a third boundary face is used to supply measurement radiation of the sensor elements to a detector of an evaluation unit. The direction of the excitation radiation is essentially normal to that of detection. The preferably different sensor elements are connected by a common sample channel, and optical and/or temporal separation of the measurement radiation of the individual sensor elements is provided.

Abstract: In a method of optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, using at least two wavelengths for measuring, a first wavelength of .lambda.<805 nm and a second wavelength of .lambda.>805 nm is employed, such the following is valid for the absorption coefficients of hemoglobin derivatives O.sub.2 Hb and RHb at the two measurement wavelengths .lambda..sub.1 and .lambda..sub.2 : .sigma.O(.lambda..sub.1).about..sigma.R(.lambda..sub.2) and .sigma.R(.lambda..sub.1).about..sigma.O(.lambda..sub.2). The sum of absorption values A.sub.1 and A.sub.2 measured at wavelengths .lambda..sub.1 and .lambda..sub.2 will be a quantity which is proportional to the total hemoglobin concentration tHb and independent of the oxygen saturation O.sub.2sat.

Abstract: An optical indicator for determining the activity of an ion in a sample is provided with an ionophor which is capable of selectively binding the ion to be measured. The ionophor has at least two functional groups that can form an electron donor acceptor (EDA) complex, the complex bond being broken up by the attachment of the ion to be determined. This will lead to a change in at least one of the measurable optical properties of the indicator in dependence on the activity of the ion to be measured.