Abstract: The present invention relates to a method, and to a corresponding device, for analyzing chemical or biological samples in which chemical or biological samples and/or targets (probes) are applied in the form of individual defined spots to an outer cylindrical jacket surface of a support, or are aliquoted in the form of fluid droplet into drill holeswhick are chased in the jacket surface of the support. The support is inserted into a recess in a retainer, which recess is essentially complementary to the cylindrical jacket surface, the samples and/or targets are acted upon by way of physical and/or chemical interactions, and the correspondingly modified spots are then analyzed. The present invention provides an analytical system which provides unambiguously defined reaction volumes, which is easy to standardize and which can be automated to a high degree.