Patents Assigned to Axcelon Biopolymers Corporation
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Patent number: 9206414Abstract: Anisotropic nanocomposite hydrogel materials are created using a process in which a hydrogel-forming material is crosslinked in the presence of nanoscale cellulose and subsequently thermally cycled under an applied tensile strain. Such materials are capable of exhibiting high mechanical and viscoelastic anisotropy, increased stiffness when subjected to large strain, and are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such nanocomposite materials.Type: GrantFiled: February 19, 2009Date of Patent: December 8, 2015Assignee: AXCELON BIOPOLYMERS CORPORATIONInventors: Wan-Kei Wan, Leonardo Millon
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Patent number: 9200086Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.Type: GrantFiled: February 4, 2013Date of Patent: December 1, 2015Assignee: AXCELON BIOPOLYMERS CORPORATIONInventors: Wankei Wan, Ganesh Guhados
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Patent number: 9186436Abstract: Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials.Type: GrantFiled: July 10, 2008Date of Patent: November 17, 2015Assignee: AXCELON BIOPOLYMERS CORPORATIONInventors: Wan-Kei Wan, Leonardo Millon
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Patent number: 8956638Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.Type: GrantFiled: April 8, 2011Date of Patent: February 17, 2015Assignee: Axcelon Biopolymers CorporationInventors: Wankei Wan, Donna Padavan
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Patent number: 8940337Abstract: A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or/and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength.Type: GrantFiled: December 23, 2010Date of Patent: January 27, 2015Assignee: Axcelon Biopolymers CorporationInventors: Xinsheng Li, Wankei Wan, Chandrakant J. Panchal
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Patent number: 8551502Abstract: Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials.Type: GrantFiled: October 31, 2007Date of Patent: October 8, 2013Assignee: Axcelon Biopolymers CorporationInventors: Wan-Kei Wan, Leonardo Millon
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Publication number: 20130211308Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio- group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.Type: ApplicationFiled: February 4, 2013Publication date: August 15, 2013Applicant: AXCELON BIOPOLYMERS CORPORATIONInventor: AXCELON BIOPOLYMERS CORPORATION
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Publication number: 20130143325Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.Type: ApplicationFiled: April 8, 2011Publication date: June 6, 2013Applicant: AXCELON BIOPOLYMERS CORPORATIONInventors: Wankei Wan, Donna Padavan
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Patent number: 8367089Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.Type: GrantFiled: April 24, 2007Date of Patent: February 5, 2013Assignee: Axcelon Biopolymers CorporationInventors: Wankei Wan, Ganesh Guhados
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Publication number: 20090220560Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.Type: ApplicationFiled: April 24, 2007Publication date: September 3, 2009Applicant: AXCELON BIOPOLYMERS CORPORATIONInventors: Wankei Wan, Ganesh Guhados