Patents Assigned to Axcelon Biopolymers Corporation
  • Patent number: 9206414
    Abstract: Anisotropic nanocomposite hydrogel materials are created using a process in which a hydrogel-forming material is crosslinked in the presence of nanoscale cellulose and subsequently thermally cycled under an applied tensile strain. Such materials are capable of exhibiting high mechanical and viscoelastic anisotropy, increased stiffness when subjected to large strain, and are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such nanocomposite materials.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: December 8, 2015
    Assignee: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wan-Kei Wan, Leonardo Millon
  • Patent number: 9200086
    Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: December 1, 2015
    Assignee: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wankei Wan, Ganesh Guhados
  • Patent number: 9186436
    Abstract: Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: November 17, 2015
    Assignee: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wan-Kei Wan, Leonardo Millon
  • Patent number: 8956638
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: February 17, 2015
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wankei Wan, Donna Padavan
  • Patent number: 8940337
    Abstract: A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or/and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 27, 2015
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Xinsheng Li, Wankei Wan, Chandrakant J. Panchal
  • Patent number: 8551502
    Abstract: Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 8, 2013
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wan-Kei Wan, Leonardo Millon
  • Publication number: 20130211308
    Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio- group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.
    Type: Application
    Filed: February 4, 2013
    Publication date: August 15, 2013
    Applicant: AXCELON BIOPOLYMERS CORPORATION
    Inventor: AXCELON BIOPOLYMERS CORPORATION
  • Publication number: 20130143325
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Application
    Filed: April 8, 2011
    Publication date: June 6, 2013
    Applicant: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wankei Wan, Donna Padavan
  • Patent number: 8367089
    Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: February 5, 2013
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wankei Wan, Ganesh Guhados
  • Publication number: 20090220560
    Abstract: Nanosilver coated bacterial cellulose nanofiber and a method of producing the nanosilver coated bacterial cellulose nanofiber. The nanosilver coated bacterial cellulose nanofiber is produced by preparing a suspension of bacterial cellulose fibers, oxidizing bacterial cellulose fibers; adding the thio-group to the polymer backbone; reacting the resulting product with silver proteinate and enhancing the nanosilver particle size. The nanosilver coated bacterial cellulose nanofibers exhibit antimicrobial properties.
    Type: Application
    Filed: April 24, 2007
    Publication date: September 3, 2009
    Applicant: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wankei Wan, Ganesh Guhados