Abstract: The present invention relates to a process for purifying lipopeptides. More particular, the invention provides an improved method for purifying daptomycin.
Type:
Application
Filed:
February 19, 2010
Publication date:
September 9, 2010
Applicant:
AXELLIA PHARMACEUTICALS APS
Inventors:
Martin Mansson, Eli Karin Dale, Sissel Hauge, Carsten Overballe-Petersen, Kjersti Aastorp Hirth, Dennis Brian Hansen
Abstract: A method for purification of the antibiotic mupirocin (pseudomonic acid A) which comprises: a) Causing or allowing precipitation of mupirocin from an aqueous solution thereof; b) Recovering the precipitate; c) Dissolving the recovered precipitate in an organic solvent.
Type:
Grant
Filed:
February 21, 2006
Date of Patent:
November 17, 2009
Assignee:
Axellia Pharmaceuticals ApS
Inventors:
Marc Antonius Theodorus Bisschops, Tiemen Geert Pieter Reijns, Anita Mathiesen, Lene Aassveen
Abstract: The present invention relates to methods for the preparation and purification of mupirocin calcium. The process comprises adsorbing mupirocin to a hydrophobic adsorbent resin, exposing the bound mupirocin to a calcium-containing solution, washing impurities from the resin and eluting purified mupirocin calcium from the resin.