Abstract: The present invention is directed to the use of a compound stimulating deubiquitinating activity in a cell for the manufacture of a medicament for enhancing the expression of integral membrane proteins on the cell surface. Especially, the invention is directed to the use of such compound for the manufacture of a medicament for the treatment of a disease of condition selected from the group consisting of cystic fibrosis, diabetes insipidus, hypercholesterinaemia and long QT-syndrome-2.
Type:
Application
Filed:
January 27, 2010
Publication date:
May 27, 2010
Applicant:
Axentis Pharma AG
Inventors:
Michael Freissmuth, Tetyana Kirpenko, Christian Nanoff, Volodymyr M. Korkhov