Abstract: The present invention relates to synthetic capsaicyns, tautomers or salts thereof and their use as bioenhancers. More particularly, the invention provides synthetic capsaicyns acting as inhibitors of certain Cytochrome P450 (CYP) isoforms. Further, the invention relates to compositions comprising capsaicyns for use as bioenhancers on active substances metabolized by CYP1A2 and CYP2D6. Such compositions or compounds may preferably be for oral administration of pharmaceuticals, nutraceuticals and supplements, increasing the bioavailability of the active substances.
Type:
Application
Filed:
February 17, 2023
Publication date:
September 3, 2026
Applicant:
aXichem AB
Inventors:
Torsten HELSING, Lucas ALTEPOST, Bomi FRAMROZE, Erik LAGER
Abstract: The present invention relates to synthetic capsaicyns, tautomers or salts thereof for enhancing physical performance and/or reducing or delaying mechanical fatigue of a subject. More particularly, the invention provides compositions comprising synthetic capsaicyns of Formula (I), provided as sport diet supplements, use of the capsaicyn compounds or compositions for improving training performance, promoting accelerated recovery and/or reducing or delaying mechanical fatigue. Furthermore, compositions comprising capsaicyns for use in treatment of a disease or indication associated with physical weakness or a lack of energy, and methods for using the compounds and compositions, are provided.
Abstract: The present invention relates to synthetic capsaicin analogues, tautomers or salts thereof and their use as bioenhancers. The invention provides substituted capsaicyns for use as a bioenhancer, use as a bioenhancer on active substances, in compositions preferably for oral administration, such as in feed, food, pharmaceutical compositions or supplements.
Abstract: The present invention relates to synthetic capsaicin analogues, tautomers or salts thereof and their use as bioenhancers. The invention provides substituted capsaicyns for use as a bioenhancer, use as a bioenhancer on active substances, in compositions preferably for oral administration, such as in feed, food, pharmaceutical compositions or supplements.