Patents Assigned to Axiom Biotechnologies
-
Patent number: 6558916Abstract: The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.Type: GrantFiled: February 7, 2001Date of Patent: May 6, 2003Assignee: Axiom Biotechnologies, Inc.Inventors: Pandi Veerapandian, Gregory Kaler
-
Patent number: 6379917Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogenous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: July 28, 2000Date of Patent: April 30, 2002Assignee: Axiom BiotechnologiesInventors: Ilya Okun, Alex Okun
-
Patent number: 6287758Abstract: Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitation spectrum of the second fluorescent membrane penetrative dye. The fluorescence is then induced by illuminating the dyes at a wavelength corresponding to the excitation spectrum of the first fluorescent dye and emission is then registered at a wavelength corresponding to the emission spectrum of the second fluorescent dye (FRET). The change in the FRET is indicative of a modulation of cell membrane potential by the biologically active compounds.Type: GrantFiled: March 23, 2000Date of Patent: September 11, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun, Gregory Kaler
-
Patent number: 6280967Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short time span.Type: GrantFiled: August 5, 1999Date of Patent: August 28, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: John Ransom, Ilya Okun, Alex Okun
-
Patent number: 6242209Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short time span.Type: GrantFiled: May 10, 2000Date of Patent: June 5, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: John Ransom, Ilya Okun, Alex Okun
-
Patent number: 6096509Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: May 24, 1999Date of Patent: August 1, 2000Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun
-
Patent number: 5919646Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: August 1, 1997Date of Patent: July 6, 1999Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun
-
Patent number: 5804436Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds on a flowing suspension of cells in which a homogeneous suspension of living cells is combined with a concentration of a test compound, directed through a detection zone, and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: August 2, 1996Date of Patent: September 8, 1998Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun