Patents Assigned to Axis Shield ASA
  • Patent number: 8802382
    Abstract: The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 12, 2014
    Assignee: Axis-Shield ASA
    Inventors: Lars Orning, Anne Rian
  • Patent number: 8728800
    Abstract: The invention provides a cassette-based automated assay for homocysteine.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: May 20, 2014
    Assignee: Axis Shield ASA
    Inventors: Frank Frantzen, Arne Ludvig Faaren, Arne Kristian Nordhei
  • Patent number: 8647831
    Abstract: The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: February 11, 2014
    Assignee: Axis-Shield ASA
    Inventors: Lars Orning, Anne Rian
  • Patent number: 8545756
    Abstract: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge of said cartridge or from said pipette.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 1, 2013
    Assignee: Axis-Shield ASA
    Inventors: Jostein Holtlund, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Patent number: 8293175
    Abstract: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to receive said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge or from said pipette.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 23, 2012
    Assignee: Axis-Shield ASA
    Inventors: Jostein Holtlund, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Publication number: 20110318847
    Abstract: An assay method and kit for the detection of potential for CVD or propensity to CVD in a human or non-human animal subject, said method comprising assessing the concentration of calprotectin in a calprotectin-containing sample taken from said subject.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Applicant: Axis-Shield ASA
    Inventor: Erling SUNDREHAGEN
  • Patent number: 7632648
    Abstract: The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: December 15, 2009
    Assignee: Axis-Shield ASA
    Inventors: Lars Örning, Anne Rian
  • Patent number: 7632462
    Abstract: An assay apparatus comprising: i) an assay cartridge (52,53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to receive said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge or from said pipette.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: December 15, 2009
    Assignee: Axis-Shield ASA
    Inventors: Jostein Holtlund, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Patent number: 7501287
    Abstract: An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin immobilizing ligand and with a reporter-labelled transcobalamin binding partner and wherein signals from reporter labels which become immobilized on said substrate are detected, characterised in that one of same ligand or said binding partner comprises a first ligand or binding partner capable of specific binding to holo transcobalamin and a second ligand or binding partner capable of binding to apo transcobalamin or to holo and apo transcobalamin.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: March 10, 2009
    Assignee: Axis-Shield ASA
    Inventor: Lars Örning
  • Patent number: 7344849
    Abstract: The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or holo TC II, separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: March 18, 2008
    Assignee: Axis-Shield ASA
    Inventors: Erling Sundrehagen, Lars Örning
  • Patent number: 7294514
    Abstract: The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: November 13, 2007
    Assignee: Axis Shield ASA
    Inventor: Lars Örning
  • Patent number: 7279283
    Abstract: The invention provides an assay method for the determination of transcobalamin II (TC II) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or cobalamin bound TC II (holo TC II), separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: October 9, 2007
    Assignee: Axis-Shield ASA
    Inventors: Erling Sundrehagen, Lars Orning
  • Patent number: 7166473
    Abstract: The invention relates to an assay method for assessing a transferrin variant or combination of transferrin variants for the diagnosis and monitoring of alcoholism, and to kits for performing the assay. In particular, the invention provides a method of producing an algorithm for determining the content of a transferrin variant or combination of transferrin variants, preferably a CDT variant or combination of CDT variants, in a sample of body fluid, said method comprising: (a) obtaining at least two solutions each having known contents of asialo- (A1, A2, A3, etc.) and disialo-transferrins (D1, D2, D3, etc.); (b) determining the content in each of said solutions of a transferrin variant or combination of transferrin variants fractions substantially free from tri- and higher sialylated transferring; (c) determining the total transferrin variant content (T1, T2, T2, etc.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: January 23, 2007
    Assignee: Axis-Shield ASA
    Inventors: Erling Sundrehagen, Asgeir Husa, Ingar Eilertsen
  • Publication number: 20060240570
    Abstract: The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates.
    Type: Application
    Filed: November 26, 2003
    Publication date: October 26, 2006
    Applicant: Axis-Shield ASA
    Inventors: Lars Örning, Anne Rian
  • Publication number: 20060216766
    Abstract: A method for assaying for a protein having at least two isoforms having different glycosylation patterns, the method including contacting a sample containing the protein with a proteolytic enzyme, and detecting the content or relative content of at least one peptide fragment produced by proteolysis of the protein.
    Type: Application
    Filed: February 6, 2004
    Publication date: September 28, 2006
    Applicant: Axis-Shield ASA
    Inventor: Philip Rye
  • Publication number: 20050148022
    Abstract: The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or holo TC II, separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.
    Type: Application
    Filed: July 23, 2004
    Publication date: July 7, 2005
    Applicant: Axis-Shield ASA
    Inventors: Erling Sundrehagen, Lars Orning
  • Patent number: 6716641
    Abstract: The invention relates to a new dipstick assay for detecting and quantifying the content of an target analyte in a sample. The assay is particularly useful for example in the diagnosis and monitoring of alcoholism by the detection of asialo transferrin or carbohydrate free transferrin (CFT). Thus, provided is a dipstick for determining the content of a target analyte variant in a mixture of analyte variants in a sample, comprising: a) a sample application zone, b) a screening zone having an immobilised binding ligand having a binding affinity for a non-target analyte variant or varinats, c) a conjugate zone comprising a detector reagent, d) a reading zone for detection of said analyte.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: April 6, 2004
    Assignee: Axis-Shield ASA
    Inventor: Erling Sundrehagen
  • Patent number: 6417006
    Abstract: An assay method for detecting potential cardiovascular disease (CVD) in a vascularized subject by assessing the concentration of holo-transcobalamin II (holo-TCII) in a sample from the subject where abnormally low levels of holo-TCII are indicative of CVD or susceptibility to CVD.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: July 9, 2002
    Assignee: Axis Shield ASA
    Inventor: Erling Sundrehagen
  • Patent number: 6103478
    Abstract: The invention provides a method of assessment of carbohydrate-deficient transferrin in a transferrin containing body fluid, said method comprising the steps of:i) obtaining a transferrin containing liquid sample of or derived from a said fluid;ii) contacting said sample with a source of iron ions;iii) subsequently contacting said sample with an anionic ion exchange resin at a pH such as to cause carbohydrate-deficient transferrin to be retained by said resin;iv) subsequently contacting said resin with an eluant serving to release carbohydrate-deficient transferrin into the eluate from said resin;v) collecting a volume of said eluate substantially free from tetra- and penta-sialo transferrin; andvi) assessing the transferrin variant content in said volume of eluate.By including at least a proportion of the trisialotransferrin in the eluate, it is possible to use relatively simple assessment techniques such as turbidimetry in the assay.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: August 15, 2000
    Assignee: Axis-Shield ASA
    Inventor: Erling Sundrehagen
  • Patent number: 6063581
    Abstract: The invention relates to a method for assaying homocysteine in a sample such as blood, plasma or urine, which comprises the steps of contacting the sample with a homocysteine converting enzyme and at least one substrate for the enzyme other than homocysteine, and without chromatographic separation, assessing a non-labelled analyte selected from a homocysteine co-substrate and the homocysteine conversion products of the enzymic conversion of homocysteine by said enzyme.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: May 16, 2000
    Assignee: Axis-Shield ASA
    Inventor: Erling Sundrehagen