Patents Assigned to AXOSIM, Inc.
  • Method of using human spheroids for drug discovery
    Patent number: 12638439
    Abstract: The present invention discloses, in one embodiment, a method of using human induced pluripotent stem cells to generate three-dimensional human organ tissue for therapeutic drug toxicity and discovery?. In one embodiment, a high throughput microtiter plate is loaded with both wild type and Rett disease 3D spheroids and exposed to a drug library, and activity is measured and analyzed for disease rescue to wild type cell behavior.
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: May 26, 2026
    Assignee: AXOSIM, INC.
    Inventors: Cassiano Carromeu, Robert T. Fremeau, Jr.
  • 3D microelectrode array (MEA) for optical and electrical probing of electrogenic cells
    Patent number: 12559364
    Abstract: Disclosed herein are novel 3D microelectrode arrays (3D MEA) that include a substrate body (e.g. chip), microneedles, traces, and a well, wherein the 3D MEA provides for transfer of electrical signals on one side of the substrate body to the other side of the substrate body. Methods for using 3D MEAs to grow electrogenic cells and obtain electrophysiological signals are disclosed as well. Fabrication techniques for producing the 3D MEAs are also disclosed.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 24, 2026
    Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC., AXOSIM, Inc.
    Inventors: Swaminathan Rajaraman, Charles M. Didier, Avra Kundu, Lowry Curley, Michael J. Moore, Hieu Nguyen, Corey Rountree