Patents Assigned to Axxam S.p.A.
  • Bicyclic CX3CR1 receptor agonists
    Patent number: 11155538
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: October 26, 2021
    Assignees: Board of Regents, The University of Texas System, Axxam S.p.A.
    Inventors: Paolo Pevarello, William J. Ray, Mary Hamby, Yaima Luzardo Lightfoot, Philip Jones, Russell Thomas, Chiara Liberati, Domenica Torino, Valentina Cusano, Francesco Piscitelli, Ali Munaim Yousif, Silvia Bovolenta
  • Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
    Patent number: 10669267
    Abstract: The present invention relates to novel substituted phenoxy- and benzyloxy-piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: June 2, 2020
    Assignee: Axxam S.P.A.
    Inventors: Paolo Pevarello, Adolfo Prandi
  • SUBSTITUTED N-[2-(4-PHENOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE AND N-[2-(4-BENZYLOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE DERIVATIVES P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20190194180
    Abstract: The present invention relates to novel substituted phenoxy- and benzyloxy-piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 27, 2019
    Applicant: Axxam S.P.A.
    Inventors: Paolo Pevarello, Adolfo Prandi
  • Substituted thiazole or oxazole P2X7 receptor antagonists
    Patent number: 10167281
    Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: June 18, 2017
    Date of Patent: January 1, 2019
    Assignee: Axxam S.P.A.
    Inventors: Paolo Pevarello, Stefan Lohmer, Chiara Llberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
  • SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20170283409
    Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Application
    Filed: June 18, 2017
    Publication date: October 5, 2017
    Applicant: Axxam S.P.A.
    Inventors: Paolo Pevarello, Stefan Lohmer, Chiara LIberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
  • Substituted thiazole or oxazole P2X7 receptor antagonists
    Patent number: 9718812
    Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: August 1, 2017
    Assignee: Axxam S.P.A.
    Inventors: Paolo Pevarello, Stefan Lohmer, Chiara Llberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
  • SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20170008883
    Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Application
    Filed: February 4, 2015
    Publication date: January 12, 2017
    Applicant: Axxam S.P.A.
    Inventors: Paolo Pevarello, Stefan Lohmer, Chiara LIberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
  • Isolated photoprotein mtClytin, and use thereof
    Patent number: 7833749
    Abstract: The invention relates to the photoprotein mtClytin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein mtClytin.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: November 16, 2010
    Assignee: Axxam S.p.A.
    Inventors: Stefan Golz, Svetlana Markova, Ludmila Burakova, Ludmila Frank, Eugene Vysotski
  • LUMINESCENT STEM CELLS AND USES THEREOF
    Publication number: 20090286695
    Abstract: It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation: methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target uses of stable recombinant stem cells for in vitro testing of toxicity and/teratology of a substance.
    Type: Application
    Filed: January 10, 2007
    Publication date: November 19, 2009
    Applicant: AXXAM S.P.A.
    Inventors: Silvia Cainarca, Cinzia Nucci, Sabrina Corazza, Stefan Lohmer