Abstract: The present invention addresses the problem of providing a tablet that contains a high concentration of acetaminophen, satisfies an acetaminophen dissolution rate from the tablet of at least 80% in 15 minutes, and can be manufactured by dry direct compression. The present invention provides a tablet including: acetaminophen that has a median particle diameter in a range from 100 to 350 µm; crystalline cellulose that has a bulk density in a range from 0.10 to 0.23 g/cm3; and at least two types of disintegrants. The at least two types of disintegrants are (a) at least one disintegrant selected from the group consisting of crospovidone, croscarmellose sodium, and sodium starch glycolate, and (b) a disintegrant that is a low-substituted hydroxypropyl cellulose. The acetaminophen content per tablet is at least 86 weight%.

Abstract: The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.

Abstract: The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.