Abstract: The present invention relates to compositions useful for ameliorating or reversing naturally occurring immunosuppression or myelosuppresive, or side effects of myelosuppresive or immunosuppresive drug therapy. Medicinal fractions derived from the plant Withania Somnifera that reverse, at least in part, one or more characteristics of immunosuppression or myelosuppression and a process for manufacturing the fractions are particular aspects of the invention. Withania Somnifera medicinal fractions have additional biological activities including anti-tumor potentiating activity.

Abstract: Compositions and methods for the modulation of aberrant inositol trisphosphate concentration in neurons is disclosed. Inositol trisphosphate stimulates an increase in intraneuronal calcium ion concentration which can, if unregulated, lead to acute neurotoxicities following such insults as brain seizures, and brain anoxia/ischemia; and lead to chronic neurotoxicities in such diseases as Alzheimer's disease, Huntington's disease, Parkinson's Disease, and amyotrophic lateral sclerosis. Inhibited inositol trisphosphate production results in aberrantly low calcium ion levels leading to neuronal apoptosis.