Patents Assigned to AZAD PHARMACEUTICALS INGREDIENTS AG
  • Synthetic path to pharmaceutically acceptable Vismodegib
    Patent number: 10343998
    Abstract: The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas are disclosed.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 9, 2019
    Assignee: AZAD PHARMACEUTICAL INGREDIENTS AG
    Inventors: Christian Manfred Frech, Pasquale Gabriele Grieco, Christine Aebersold, Patrick Müller, Jan-Erik Ingenhoff, Miriam Oberholzer, Viktorya Rstakyan, Roman Gerber Aeschbacher
  • Methods for producing paricalcitol
    Patent number: 9212136
    Abstract: The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: December 15, 2015
    Assignees: AZAD PHARMACEUTICALS INGREDIENTS AG, UNIVERSITAT ZURICH
    Inventors: Thomas Bader, Alfred Stutz, Hans-Ulrich Bichsel, Changchun Fu
  • Crystalline form of pemetrexed disodium
    Patent number: 9174991
    Abstract: The present invention relates to a new polymorphic or crystalline form of Pemetrexed Disodium, processes for its preparation and its use, in particular for the preparation of medicaments.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: November 3, 2015
    Assignees: Azad Pharmaceutical Ingredients AG, University of Zurich
    Inventors: Uwe Jens Albrecht, Hannes Helmboldt, Vsevolod Valerievich Nikolaev
  • PROCESS FOR PREPARING STERILE BRINZOLAMIDE
    Publication number: 20150065493
    Abstract: Process of preparing sterile brinzolamide using ethylene-oxide gas sterilisation, sterile brinzolamide obtainable by said process and pharmaceutical compositions comprising said sterile brinzolamide.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 5, 2015
    Applicant: AZAD Pharmaceutical Ingredients AG
    Inventors: Van Van Khov-Tran, Frank Porstmann, Jan Ondracek, Gregory Grams
  • NEW CRYSTALLINE FORM OF PEMETREXED DISODIUM
    Publication number: 20120329819
    Abstract: The present invention relates to a new polymorphic or crystalline form of Pemetrexed Disodium, processes for its preparation and its use, in particular for the preparation of medicaments.
    Type: Application
    Filed: November 24, 2010
    Publication date: December 27, 2012
    Applicants: UNIVERSITY OF ZURICH, AZAD PHARMACEUTICAL INGREDIENTS AG
    Inventors: Uwe Jens Albrecht, Hannes Helmboldt, Vsevold Valerievich Nikolaev
  • PROCESS FOR PREPARING BRINZOLAMIDE
    Publication number: 20120095219
    Abstract: The present invention refers to the preparation and purification of brinzolamide as well as to novel compounds useful in such processes.
    Type: Application
    Filed: March 12, 2010
    Publication date: April 19, 2012
    Applicant: Azad Pharmaceutical Ingredients AG
    Inventors: Arul Ramakrishnan, Anil Kumar Soni, Sujit Das Adhikari, Kommula Srinivasa Rao, Soumendu Paul, Ganta Srinivasulu
  • Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
    Patent number: 7687646
    Abstract: The present invention provides a novel polymorphic form of olopatadine hydrochloride ([(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride), a selective histamine H1-receptor antagonist that is used for the treatment of ocular symptoms of seasonal allergic conjunctivitis. The present invention also provides novel methods for producing olopatadine on a large scale, and in a manner that is cost effective, provides a low level of impurities and eliminates the need to use the costly and dangerous base, butyllithium, which is used in prior art reactions for making olopatadine. The present invention further provides novel processes for carrying out a large scale production of 3-dimethylaminopropyltriphenylphosphonium bromide and its corresponding hydrobromide salt, which are employed in the production of olopatadine, and pharmaceutically acceptable salts of olopatadine.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: March 30, 2010
    Assignees: Azad Pharmaceutical Ingredients, AG, Universität Zürich
    Inventors: Thomas Bader, Hans-Ulrich Bichsel, Bruno Gilomen, Imelda Meyer-Wilmes, Mark Sundermeier