Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of novel 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1 and CX3CR1, and to their use in a method for treating or preventing diseases based on the expression of MCP-1 and CX3CR1.
Abstract: It is disclosed a packaging material for a pharmaceutical product. The packaging material comprises a coloured element which at about 38° C. discolours partially, revealing a marking. The element is formed by a first portion forming the marking printed with conventional ink, and a second portion printed with thermochromic ink. The thermochromic ink is coloured below about 38° C. and becomes colourless when this temperature is reached or exceeded. The two portions are arranged so that the first portion is invisible below about 38° C., but becomes visible when this temperature is reached or exceeded.
Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of novel 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1 and CX3CR1, and to their use in a method for treating or preventing diseases based on the expression of MCP-1 and CX3CR1.