Abstract: A compound having one of the following structures of Formula (IV) or (V): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5 R6, R7, R8, R10, R11a R11b, R12a R12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.
Type:
Grant
Filed:
March 7, 2023
Date of Patent:
December 5, 2023
Assignee:
Azora Therapeutics, Inc.
Inventors:
Matthew Davidson, Julie Saiki, Robert Lum, Steven R. Schow
Abstract: Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.
Type:
Grant
Filed:
March 5, 2021
Date of Patent:
October 26, 2021
Assignee:
Azora Therapeutics, Inc.
Inventors:
Matthew Davidson, Julie Saiki, Johan Andreasson