Patents Assigned to AZURA OPHTHALMICS LTD.
  • Patent number: 11643429
    Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory/infections disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugate which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eye, ocular surface or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: May 9, 2023
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Marc Gleeson, Mark Richard Stewart, Jonathan Dunn
  • Patent number: 11634411
    Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 25, 2023
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Marc Gleeson, Mark Richard Stewart, Robert M. Burk, Jonathan Dunn, Nicholas Chapman
  • Patent number: 11633410
    Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: April 25, 2023
    Assignee: AZURA OPHTHALMICS LTD
    Inventors: Yair Alster, Omer Rafaeli, Kirsten Angela Macfarlane, Cary Reich, Shimon Amselem, Doron Friedman
  • Patent number: 11517586
    Abstract: Provided herein are methods treating a disease or disorder in or around the eye with a pharmaceutical composition comprising selenium disulfide (SeS2) and instructing the treated individual to limit or avoid exposure to light following administration in order to reduce the adverse effect of the composition.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: December 6, 2022
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Yair Alster, Charles Bosworth, Hila Epstein-Barash, Omer Rafaeli
  • Patent number: 11484516
    Abstract: Described herein are compositions and methods for the increasing the quantity of lipids secreted from meibomian glands. Such compositions and methods are useful for the treatment of meibomian gland dysfunction and disorders resulting therefrom.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: November 1, 2022
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Shimon Amselem, Yair Alster, Doron Friedman, Omer Rafaeli
  • Patent number: 11459351
    Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: October 4, 2022
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Robert M. Burk, Marc Gleeson, Mark Richard Stewart, Jonathan Dunn, Alexander James Nicholls
  • Patent number: 11324775
    Abstract: Described herein are compositions and methods for the treatment of contact lens discomfort (CLD) and/or lid wiper epitheliopathy (LWE). Such compositions comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of such compositions to the inner surface of the eyelid provides therapeutic benefit to patients suffering from contact lens discomfort (CLD) and/or lid wiper epitheliopathy (LWE).
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: May 10, 2022
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Charles Bosworth, Yair Alster, Hila Epstein-Barash, Omer Rafaeli, Marc Gleeson
  • Patent number: 11040062
    Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said methods are performed by administering said composition comprising a selenium disulfide and an anhydrous semi-solid base. The stable anhydrous composition are substantially free of selenium disulfide agglomerates.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: June 22, 2021
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Doron Friedman, Yair Alster, Omer Rafaeli, Shimon Amselem, Zakhar Nudelman
  • Patent number: 11013749
    Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: May 25, 2021
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Yair Alster, Omer Rafaeli, Kirsten Angela Macfarlane, Cary Reich, Shimon Amselem, Doron Friedman
  • Patent number: 10875845
    Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: December 29, 2020
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Marc Gleeson, Mark Richard Stewart, Robert M. Burk, Jonathan Dunn, Nicholas Chapman
  • Patent number: 10772899
    Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: September 15, 2020
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Yair Alster, Omer Rafaeli, K. Angela MacFarlane, Cary Reich, Shimon Amselem, Doron Friedman
  • Patent number: 10688122
    Abstract: Described herein are compositions and methods for the increasing the quantity of lipids secreted from meibomian glands. Such compositions and methods are useful for the treatment of meibomian gland dysfunction and disorders resulting therefrom.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: June 23, 2020
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Shimon Amselem, Yair Alster, Doron Friedman, Omer Rafaeli
  • Patent number: 10588915
    Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: March 17, 2020
    Assignee: AZURA OPHTHALMICS LTD.
    Inventors: Yair Alster, Omer Rafaeli, K. Angela MacFarlane, Cary Reich, Shimon Amselem, Doron Friedman