Patents Assigned to B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University
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Publication number: 20180099006Abstract: Disclosed herein are compositions, methods and uses utilizing alginate compositions, for treating, preventing and/or reducing liver damage induced by a hepatotoxic agent, and for treating a medical condition treatable by a hepatotoxic agent, in which an alginate composition is administered prior to, concomitant with, or shortly after exposure to a hepatotoxic agent. Also disclosed are pharmaceutical compositions comprising a hepatotoxic agent and an alginate composition and uses thereof for treating medical conditions treatable by the hepatotoxic agent.Type: ApplicationFiled: December 11, 2017Publication date: April 12, 2018Applicants: Hadasit Medical Research Services and Development Ltd., B.G. Negev Technologies & Applications Ltd., at Ben-Gurion UniversityInventors: Smadar COHEN, Yaron ILAN, Eyal SHTEYER, Ami BEN-YA'ACOV
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Patent number: 9934131Abstract: An artificial intelligence based method for improving a software testing process, according to which upon finding a bug, a set of candidate diagnoses is proposed to the tester, based on a Model-Based Diagnosis (MBD) process. A planning process is used for automatically suggesting further test steps to be performed by the tester, to identify the correct diagnosis for the developer in the form of faulty software component that caused the bug, while minimizing the tests steps performed by the tester. Additional information is provided to the MBD process, based on the outputs of the further test steps, thereby pruning incorrect candidate diagnoses. These steps are iteratively repeated while in each time, minimizing the set of candidate diagnoses, until a single diagnosis remains in the set.Type: GrantFiled: February 5, 2015Date of Patent: April 3, 2018Assignee: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Meir Kalech, Ron Stern
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Publication number: 20180078923Abstract: The invention relates to potassium-promoted, Fe2+(Fe3+yAl3+i-y)2o4 [0.3<y?0.7] silica-containing extrudates, processes for the preparation of the extrudates with the aid of colloidal silica, and the use of the extrudates to catalyze processes for producing liquid hydrocarbons.Type: ApplicationFiled: April 6, 2016Publication date: March 22, 2018Applicant: B.G. Negev Technologies and Applications LTD., at Ben-Gurion UniversityInventors: Mordechay Herskowitz, Miron Landau, Roksana Vidruk, Meital Amouyal
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Patent number: 9895420Abstract: The present invention provides a chimera protein made of amino acid residues derived from IL-1beta propeptide and the IL-1Ra mature peptide and polynucleotides encoding the protein. The present invention also provides usages of the protein and the polynucleotides in pharmaceutical compositions that treat inflammation.Type: GrantFiled: June 5, 2014Date of Patent: February 20, 2018Assignees: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN GURION UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Eli Lewis, Peleg Rider, Charles A. Dinarello
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Patent number: 9891593Abstract: The present invention relates to the realization of an ADC by using a one shot time cell as an analog-to-time converter and a time-to-digital converter. The present invention relates in general, to the design and Integrated Circuit (IC) implementation of a fully-digital fully-synthesizable, delay-line analog-to-digital converter (DL-ADC). The present invention is specifically relevant for power management applications where the silicon area of the controller is of key importance. The design of the ADC is based on the approach of delay cells string to reduce design complexity and the resultant of the silicon area.Type: GrantFiled: May 17, 2015Date of Patent: February 13, 2018Assignee: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Mor Mordechai Peretz, Yevgeny Bezdenezhnykh
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Publication number: 20170302172Abstract: The present invention introduces a new compact Voltage Regulator Module (VRM) solution that hybrids a buck converter with a resonant switched-capacitor auxiliary circuit that is connected at the load side. By using a new control concept of the present invention, the auxiliary circuit effectively mimics increased capacitance during loading and unloading transient events, reducing the burden on both the input and output filters, and reduces the current stress.Type: ApplicationFiled: September 7, 2015Publication date: October 19, 2017Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Mor Mordechai Peretz, Alon Cervera, Or Kirshenboim
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Publication number: 20170292139Abstract: This invention relates to methods of producing a rare amino acid- or non-natural amino acid-containing protein in a cell free protein synthesis system and kits for use in and for accomplishing same. Specifically, the methods comprise the steps of expressing at least one orthogonal suppressor tRNA (o-tRNA)/aminoacyl-tRNA synthetase (aaRS) pair or derivatives thereof specific for incorporation of a rare amino acid- or non-natural amino acid in an E. coli organism; preparing a lysate of said E.Type: ApplicationFiled: June 17, 2015Publication date: October 12, 2017Applicant: B.G NEGEV TECHNOLOGIES AND APPLICATIONS LTD., at BEN-GURION UNIVERSITYInventors: Lital ALFONTA, Yonatan CHEMLA, Eden OZER
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Publication number: 20170258735Abstract: Provided are co-assembled nanoparticles including at least one polypeptide including a polyanion; and at least one amphiphilic peptide capable of forming a ?-sheet structure, a derivative or a salt thereof, the amphiphilic peptide including at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues in which the hydrophilic amino acid residue is positively charged, and methods of preparation of the nanoparticles. Further provided are pharmaceutical compositions including the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co-assembled nanoparticles. Further provided are therapeutic uses of the pharmaceutical compositions.Type: ApplicationFiled: May 13, 2015Publication date: September 14, 2017Applicant: B. G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Hanna RAPAPORT, Ifat COHEN
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Patent number: 9758559Abstract: The present invention relates to short peptides based on the amino acids sequence of the N-terminal domain of the human mitochondrial protein voltage-dependent anion channel 1 (VDAC) and to peptide conjugates having a cell permeability enhancing moiety. The peptides, peptide conjugates and pharmaceutical compositions containing them are useful for treating diseases characterized by cell hyperproliferation or resistance to cell death and in particular, cancer.Type: GrantFiled: July 24, 2014Date of Patent: September 12, 2017Assignees: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University, The National Institute for Biotechnology in the Negev Ltd.Inventor: Varda Shoshan-Barmatz
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Publication number: 20170247286Abstract: The invention relates to a composition for producing a solar absorber coating, comprising a silicone resin formulated with: (i) at least one compound selected from the group consisting of black ruthenium oxides and black spinel; and (ii) a glass powder. A method of applying the composition and coatings formed are also provided.Type: ApplicationFiled: August 17, 2015Publication date: August 31, 2017Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventor: Jacob HORMADALY
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Publication number: 20170189864Abstract: The present invention discloses stable composite membranes comprising a porous support having one or more thin selective layers coated on a top surface thereof, whereas at least one of said thin selective layers comprises a crosslinked fluorinated silicone polymer, and further wherein the total thickness of said one or more thin selective layers ranges between 0.1 to 10 microns. The use of these membranes in the process of olive oil wastewater treatment and the valorization of polyphenol-rich by-products, are also disclosed.Type: ApplicationFiled: May 27, 2015Publication date: July 6, 2017Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Jack GILRON, Charles LINDER, Zeev WIESMAN
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Publication number: 20170171050Abstract: The present invention relates to a system and method for mediating between SDN based networks and common flow-monitoring systems. The present invention transfer data from an SDN controller, to a traditional flow monitoring system, by using a proxy based method within the NFO (Net Flow for Open Flow) framework. In an embodiment of the invention, the invention relates to a flow discovery method, which can efficiently discover newly active flows that pass through the network and so the present invention collects data and statistic in a very effective way while spending resources only on flows that need to be monitored.Type: ApplicationFiled: February 15, 2015Publication date: June 15, 2017Applicant: B.G. Negev Technologies and Application Ltd., at Ben-Gurion UniversityInventors: Rami PUZIS, Luiza NACSHON
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Publication number: 20170153967Abstract: An artificial intelligence based method for improving a software testing process, according to which upon finding a bug, a set of candidate diagnoses is proposed to the tester, based on a Model-Based Diagnosis (MBD) process. A planning process is used for automatically suggesting further test steps to be performed by the tester, to identify the correct diagnosis for the developer in the form of faulty software component that caused the bug, while minimizing the tests steps performed by the tester. Additional information is provided to the MBD process, based on the outputs of the further test steps, thereby pruning incorrect candidate diagnoses. These steps are iteratively repeated while in each time, minimizing the set of candidate diagnoses, until a single diagnosis remains in the set.Type: ApplicationFiled: February 5, 2015Publication date: June 1, 2017Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Meir KALECH, Ron STERN
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Patent number: 9651504Abstract: The invention is a method of Fano resonance microwave spectroscopy of high absorption matter. The method comprises: embedding a magnetic-dipolar-mode (MDM) ferrite disk in the microwave cavity, loading a sample of the high absorption matter in the microwave cavity, using a bias magnetic field to tune the MDM resonance frequency of the ferrite disk to the resonance frequency of the cavity; and observing the symmetric Lorentz-like lineshape of the resonance peaks that are obtained.Type: GrantFiled: July 29, 2015Date of Patent: May 16, 2017Assignee: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Guy Vaisman, Evgeny Elman, Elad Hollander, Eugene O. Kamenetskii, Reuven Shavit
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Publication number: 20170059299Abstract: The invention is a system and method that enable obtaining ultra-high resolution interference, phase and OCT images at high speed. The system uses neither mechanical moving elements nor any optical/electro optical modulating means for obtaining the OCT images. Two OCT operating modes are available: for ultra-high resolution the system allows either spatial coherence TD-FF-OCT or temporal coherence TD-FF-OCT imaging, whereas for high resolution and ultra-high speed the system allows FD-FF-OCT imaging with full range imaging. In the TD mode, the OCT enface images are obtained in real time. In the FD mode, the 2D complex signal is reconstructed in real time. In both cases the method has the advantage of very high speed imaging with great immunity to noise.Type: ApplicationFiled: February 3, 2015Publication date: March 2, 2017Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventors: Avner SAFRANI, Ibrahim ABDULHALIM
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Patent number: 9522386Abstract: The invention relates to a catalyst suitable for use in the hydrogenation of carbon dioxide-containing gas, said catalyst comprising spinel phase of the formula [Fe2+(Fe3+yAl3+1-y)2O4]. Processes for preparing the catalyst and processes for the hydrogenation of carbon dioxide-containing gas in the presence of the catalyst are also disclosed.Type: GrantFiled: July 16, 2015Date of Patent: December 20, 2016Assignee: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. AT BEN-GURION UNIVERSITYInventors: Miron Landau, Mordechai Herskowitz, Roksana Vidruk
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Publication number: 20160344153Abstract: The invention is optical configurations for constructing laser oscillators or laser amplifiers that comprise an extremely short fiber (typically tens of cm long or below, e.g. 5 cm to 30 cm). In order to overcome the absorption limitation due to the very short length of the fiber, the present invention employs a multi pump-pass scheme for pump light confinement. This scheme is based on the small angular overlap between the lasing and pump beams. The multi pump-pass method of the invention leads to efficient fiber laser oscillators and amplifiers having pulse duration of a few ns, with high average and peak power output that is comparable to the state-of-the-art solid state lasers.Type: ApplicationFiled: January 20, 2015Publication date: November 24, 2016Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN GURION UNIVERSITYInventors: Amiel A. ASHAAYA, Boris ROSENSTEIN LEVIN
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Patent number: 9399667Abstract: Specific peptides derived from the cytotoxicity receptor natural killer protein 44 (NKp44) useful for treating diseases such as cancer are described. The invention further relates to compositions comprising a fragment of the extracellular region of NKp44 for preventing or treating cancer.Type: GrantFiled: September 22, 2014Date of Patent: July 26, 2016Assignee: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITYInventor: Angel Porgador
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Publication number: 20160176937Abstract: The present invention relates to short peptides based on the amino acids sequence of the N-terminal domain of the human mitochondrial protein voltage-dependent anion channel 1 (VDAC) and to peptide conjugates having a cell permeability enhancing moiety. The peptides, peptide conjugates and pharmaceutical compositions containing them are useful for treating diseases characterized by cell hyperproliferation or resistance to cell death and in particular, cancer.Type: ApplicationFiled: July 24, 2014Publication date: June 23, 2016Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN GURION UNIVERSITYInventor: Varda SHOSHAN-BARMATZ