Patents Assigned to B.S.R.C. "ALEXANDER FLEMING"
  • TNF SUPERFAMILY TRIMERIZATION INHIBITORS
    Publication number: 20140165223
    Abstract: Described are methods and compositions for inhibiting the trimerization of ligands belonging to the TNF superfamily, in particular, inhibiting RANKL trimerization. Accordingly, the methods and compositions provided herein can be used to treat disorders associated with increased RANK signaling, in particular those related to bone loss. Compounds that inhibit trimerization of ligands belonging to the TNF superfamily are also described.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 12, 2014
    Applicant: B.S.R.C. "Alexander Fleming"
    Inventors: Eleni Ntouni, Georgios Kollias
  • AUTOTAXIN PATHWAY MODULATION AND USES THEREOF
    Publication number: 20130202614
    Abstract: Disclosed are methods for preventing, treating, or reducing symptoms of a disorder involving the autotaxin (ATX) pathway. In one embodiment, the method features administering to a mammal a sufficient amount of an autotaxin (ATX) or lysophosphatidic acid (LPA) signaling inhibitor, to prevent, treat or reduce symptoms of an inflammatory disorder, autoimmune disorder, fibrosis or malignancy of the lung. Further disclosed are methods for diagnosing an autotaxin-related disorder as well as kits for performing the methods of the invention.
    Type: Application
    Filed: December 4, 2012
    Publication date: August 8, 2013
    Applicant: B.S.R.C. "ALEXANDER FLEMING"
    Inventor: B.S.R.C. "Alexander Fleming"