Abstract: In the measurement of properties of a wafer substrate, such as Critical Dimension or overlay a sampling plan is produced 2506 defined for measuring a property of a substrate, wherein the sampling plan comprises a plurality of sub-sampling plans. The sampling plan may be constrained to a predetermined fixed number of measurement points and is used 2508 to control an inspection apparatus to perform a plurality of measurements of the property of a plurality of substrates using different sub-sampling plans for respective substrates, optionally, the results are stacked 2510 to at least partially recompose the measurement results according to the sample plan.

Abstract: A supercontinuum radiation source for an alignment mark measurement system comprises: a radiation source; illumination optics; a plurality of waveguides; and collection optics. The radiation source is operable to produce a pulsed radiation beam. The illumination optics is arranged to receive the pulsed pump radiation beam and to form a plurality of pulsed sub-beams, each pulsed sub-beam comprising a portion of the pulsed radiation beam. Each of the plurality of waveguides is arranged to receive at least one of the plurality of pulsed sub-beams beam and to broaden a spectrum of that pulsed sub-beam so as to generate a supercontinuum sub-beam. The collection optics is arranged to receive the supercontinuum sub-beam from each of the plurality of waveguides and to combine them so as to form a supercontinuum radiation beam.

Abstract: Cell targeting conjugates that comprise a targeting moiety and one or more functional moieties bound thereto via a linker, wherein the linker comprises a transition metal complex and wherein at least 90% of the conjugates have a ratio of functional moieties to targeting moieties (DAR) of or less. A pharmaceutical composition comprising the cell targeting conjugates and the use of the conjugates and composition as a medicament, in particular, in the treatment of cancer.

Abstract: A new and distinct cultivar of Chrysanthemum plant named ‘DLFVIBE2’, characterized by its upright plant habit; vigorous growth habit; dark green-colored leaves; uniform and freely flowering habit; strong upright flowering stems with numerous inflorescences; single-type inflorescences with bright yellow-colored ray florets and bright green-colored disc florets; and relative tolerance to high and low production temperatures.

Abstract: The present invention is directed to particle comprising a drug and a ligand, and to method of making them and use thereof. Particularly, the present invention results in the covalent entrapment of drug(s) in high amounts in polymer carriers, such as (nano)particle, microspheres and other types of polymer devices for controlled release. The polymer carriers or devices can be decorated with ligands, allowing for targeting specific tissues and/or (non-) invasive monitoring.

Abstract: A new and distinct cultivar of Chrysanthemum plant named ‘DLFSCO1’, characterized by its upright plant habit; vigorous growth habit; dark green-colored leaves; uniform and freely flowering habit; strong upright flowering stems with numerous inflorescences; relatively small decorative pompon-type inflorescences with bright green to white-colored ray florets; and excellent postproduction longevity.

Abstract: The present invention relates to anti-CD27 antibodies, as well as use antibodies in the treatment of diseases such as cancer and infectious disease.

Abstract: A lighting-system (100) for illuminating an environment, the lighting system comprising a plurality of lighting modules (111, 112, 113) and a lighting-system control device (130). The lighting modules comprise: —a light source (121) for emitting light, —a programmable controller (122) configured to control an operation of the light source, and —a network interface (123) configured to allow the lighting module to communicate via a network. The lighting-system control device (130) comprises: —a processor circuit (133) configured to determine lighting control data to change the light spectrum of the light source based on the mobility data of the at least one user, and to transmit the lighting control data to at least one lighting module of the plurality of lighting modules to program said lighting module according to the lighting control data.

Abstract: A lithographic projection apparatus is disclosed in which a space between the projection system and the substrate is filled with a liquid. An edge seal member at least partly surrounds the substrate or other object on a substrate table to prevent liquid loss when edge portions of the substrate or other object are, for example, imaged or illuminated. A lithographic projection apparatus includes a support structure configured to hold a patterning device, the patterning device configured to pattern a beam of radiation according to a desired pattern; a substrate table configured to hold a substrate; a projection system configured to project the patterned beam onto a target portion of the substrate; a liquid supply system configured to provide liquid to a space between the projection system and the substrate; and a shutter configured to isolate the space from the substrate or a space to be occupied by a substrate.

Abstract: The invention relates to a surgical device for minimally invasive surgery, comprising a shaft and a surgical module mounted to the distal end thereof. The shaft includes a tube and a pair of sliders driven by the tube via a rotary to linear linkage such that a rotation of the tube around the longitudinal axis induces a movement of the sliders along the longitudinal axis, in mutually opposite directions. The surgical device further includes wires that are each connected to a corresponding slider and to the surgical module such that a movement of the sliders, in mutually opposite directions, induces a movement of the surgical module in a first degree of freedom. The tube is also axially moveable towards the proximal end of the shaft inducing a movement of both sliders away from the surgical module, thereby inducing a movement of the surgical module in a second degree of freedom.

Abstract: A method of patterning lithographic substrates, the method including using a free electron laser to generate EUV radiation and delivering the EUV radiation to a lithographic apparatus which projects the EUV radiation onto lithographic substrates, wherein the method further includes reducing fluctuations in the power of EUV radiation delivered to the lithographic substrates by using a feedback-based control loop to monitor the free electron laser and adjust operation of the free electron laser accordingly.

Abstract: A new and distinct cultivar of Chrysanthemum plant named ‘DLFBRI1’, characterized by its upright plant habit; vigorous growth habit; relatively rapid growth rate; dark green-colored leaves; uniform and freely flowering habit; strong upright flowering stems with numerous inflorescences; and large decorative-type inflorescences with white-colored ray florets.

Abstract: The invention provides a method for forming a building element, comprising defining in a computer memory: a building element parametric three-dimensional (3D) model of a building element, and a building element constraint space, said building element constraint space comprising building element dimensional parameters of said building element that are mathematically coupled to at least one selected from another dimensional parameter of the building element, a minimum value, a maximum value, and a combination thereof; said method further comprising running a computer program on a computer system which: retrieves from said computer memory said building element parametric 3D model and its linked constraint space; visualises said building element parametric 3D model through a display system; provides a user tool which is visualised through said display system and which allows a user to modify one or more building element dimensional parameters to provide an amended building element parametric 3D model by receiv

Abstract: Embodiments are provided that include a method for fabricating a multi-die package including: placing a plurality of flip chip dies and splitter dies on the sacrificial carrier; performing solder reflow to join solder bumps of each flip chip die and each splitter die to the sacrificial carrier that includes test probe circuitry; testing the flip chip and splitter dies; replacing any faulty dies; overmolding the flip chip and splitter dies on the sacrificial carrier to form a panel of embedded dies; planarizing the panel of embedded dies to expose back surfaces of the embedded dies; forming a metallization layer across the back surface of the panel of embedded dies; and removing the sacrificial carrier to expose a front surface of the panel of embedded dies, wherein a contact surface of each solder bump of each flip chip die and splitter die is exposed in the front surface.

Abstract: A method of facilitating a device to obtain a version of an item of content. For each section of the item of content, a content distribution system is arranged to provide one or more versions of that section. At least one section includes a plurality of differently watermarked versions of that section. A request for a section of the item of content is received. If the requested section is a section for which the content distribution system is arranged to provide a plurality of differently watermarked versions of that section, a particular version is identified based on an identifier of the device and a response a response containing an indication of the particular version of the requested section is provided to the device. The response is arranged to cause the device to request the particular version of the requested section from a corresponding location on the content distribution system.

Abstract: A user interface for at least one media processing apparatus includes a display device connected to an apparatus control system and arranged to visualize timings of events occurring or expected to occur in a processing sequence of the apparatus, the timings being visualized by showing an indication of each event on a timeline that has a certain time scale and a certain zero point, wherein the timeline has at least two sections which differ in the time scale and/or the zero point.

Abstract: A mold apparatus comprising: a core portion comprising a core surface, a first induction coil, and an inner core, and wherein the core portion has a core portion mass; a cavity portion comprising a second induction coil and a cavity surface, and wherein the cavity portion has a cavity portion mass; wherein the inner core comprises a non-magnetic material, the core surface comprises a magnetic material, and a density of the non-magnetic material is less than a density of the magnetic material; and wherein the core portion mass and the cavity portion mass differ by less than or equal to than 5%.

Abstract: A sinusoidal traffic line that has scalloped edges to form a sine wave that increases visibility under conditions of reduced visibility is formed of a pre-cut ribbon or applied traffic line material (e.g., sprayed thermoplastic material). The traffic lines have a wavy left edge and a wavy right edge. The edges are formed in a regular pattern, having a regular amplitude and wavelength relative to a directional vector along the axis of the traffic line. The patterns of the outer edges are arranged in an opposite arrangement such that they converge and diverge. The upper surface of the traffic line can be embossed by an embossed device so as to create a regular pattern and increase reflectivity.

Abstract: A reference voltage circuit with current buffer including a low voltage reference to output a low voltage, a first resistor-capacitor (RC) filter to filter the low voltage, a buffer circuit to output a current to be used by a load, a second RC filter associated with the load, and a capacitor in parallel with the buffer circuit configured to increase a rise time of the buffer.

Abstract: Apparatuses, systems and methods for providing improved intraocular lenses (IOLs), include features for reducing side effects, such as halos, glare and best focus shifts, in multifocal refractive lenses and extended depth of focus lenses. Exemplary ophthalmic lenses can include a continuous, power progressive aspheric surface based on two or more merged optical zones, the aspheric surface being defined by a single aspheric equation. Continuous power progressive intraocular lenses can mitigate optical side effects that typically result from abrupt optical steps. Aspheric power progressive and aspheric extended depth of focus lenses can be combined with diffractive lens profiles to further enhance visual performance while minimizing dysphotopsia effects. The combination can provide an increased depth of focus that is greater than an individual depth of focus of either the refractive profile or the diffractive profile.