Patents Assigned to BAC IP B.V.
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Patent number: 10259886Abstract: The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.Type: GrantFiled: May 1, 2015Date of Patent: April 16, 2019Assignee: BAC IP B.V.Inventors: Wilhelmus Josephus Johanna Hermans, Sandra Bezemer, Yvonne Mathalie Mijnsbergen
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Patent number: 9850315Abstract: The present disclosure relates to a method for the purification of a human IgG-CH1 domain comprising molecule using an antigen-binding protein that is capable of binding to an epitope that is comprised in the CH1 domain of each of human IgG1, human IgG2, human IgG3 and human IgG4. The disclosure further relates to the antigen-binding proteins that can be used in the method of the disclosure. The frame-work regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies that naturally are devoid of light chains as may e.g. be found in camelids. The disclosure further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, and to the uses of such immunoadsorbent materials for the purification of IgG-CH1 domain containing molecules from a variety of species.Type: GrantFiled: January 31, 2012Date of Patent: December 26, 2017Assignee: BAC IP B.V.Inventors: Wilhelmus Josephus Johanna Hermans, Sven Blokland, Maria Anna van Kesteren, Johanna Magaretha Horrevoets, Franciscus Johan Marinus Detmers
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Patent number: 9080157Abstract: The use of VHHs in the preparation of products to provide stability of antibody specificity under destabilizing conditions whereby normally lower eukaryotes or traditional antibodies are killed or inactivated.Type: GrantFiled: May 2, 2012Date of Patent: July 14, 2015Assignee: BAC IP B.V.Inventors: Daniel Convents, Leo G. Frenken, Michael M. Harmsen, Richard H. van der Linden, Cornelis T. Verrips
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Patent number: 9040666Abstract: The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.Type: GrantFiled: July 8, 2008Date of Patent: May 26, 2015Assignee: BAC IP B.V.Inventors: Wilhelmus Josephus Johanna Hermans, Sandra Bezemer, Yvonne Mathalie Mijnsbergen
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Patent number: 8951755Abstract: The use of VHHs in the preparation of products to provide stability of antibody specificity under destabilizing conditions whereby normally lower eukaryotes or traditional antibodies are killed or inactivated.Type: GrantFiled: March 12, 1999Date of Patent: February 10, 2015Assignee: BAC IP B.V.Inventors: Daniel Convents, Leo G. Frenken, Michael M. Harmsen, Richard H. van der Linden, Cornelis T. Verrips
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Publication number: 20140256579Abstract: Protein arrays are provided comprising single domain antibodies obtainable from Camelidae which are capable of detecting even minor changes in the expression of proteins in cell and tissue extracts and having an optimal signal to noise ratio by removing non-informative abundant proteins from said cell or tissue extracts.Type: ApplicationFiled: February 6, 2014Publication date: September 11, 2014Applicant: BAC IP B.V.Inventors: Johannes Joseph DE HAARD, Pim HERMANS, Ilse LANDA, Theodorus Cornelis VERRIPS
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Publication number: 20130337478Abstract: The present disclosure relates to a method for the purification of a human IgG-CH1 domain comprising molecule using an antigen-binding protein that is capable of binding to an epitope that is comprised in the CH1 domain of each of human IgG1, human IgG2, human IgG3 and human IgG4. The disclosure further relates to the antigen-binding proteins that can be used in the method of the disclosure. The frame-work regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies that naturally are devoid of light chains as may e.g. be found in camelids. The disclosure further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, and to the uses of such immunoadsorbent materials for the purification of IgG-CH1 domain containing molecules from a variety of species.Type: ApplicationFiled: January 31, 2012Publication date: December 19, 2013Applicant: BAC IP B.V.Inventors: Wilhelmus Josephus Johanna Hermans, Sven Blokland, Maria Anna van Kesteren, Johanna Magaretha Horrevoets, Franciscus Johan Marinus Detmers
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Publication number: 20110166076Abstract: The present invention relates to superantigen-specificantigen-binding proteins comprising an immunoglobulin-derived variable domain that comprises a complete antigen binding site for an epitope on the superantigen in a single polypeptide chain. The antigen-binding proteins of the invention may be used in the treatment skin diseases. The antigen-binding proteins of the invention may be used in compositions for topical administration.Type: ApplicationFiled: September 10, 2009Publication date: July 7, 2011Applicant: BAC IP B.V.Inventors: Hendrik Adams, Bram Theodorus Hendrikus Maassen
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Patent number: 7794981Abstract: A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an example DNA sequence encoding the antibody or (functionalized) fragment thereof, wherein the antibody or (functionalized) fragment thereof is derived from a heavy chain immunoglobulin of Camelidae and is devoid of light chains, and wherein the lower eukaryotic host is a mould, preferably belonging to the genera Aspergillus or Trichoderma, or a yeast, preferably belonging to the yeast genera Saccharomyces, Kluyveromyces, Hansenula, or Pichia. The heavy chain fragment can contain at least the whole variable domain. A complementary determining region (CDR) different from the CDR belonging to the natural antibody ex Camelidae can be grafted on the framework of the variable domain of the heavy chain immunoglobulin. The catalytic antibodies can be raised in Camelidae against transition state molecules.Type: GrantFiled: August 11, 2004Date of Patent: September 14, 2010Assignee: BAC IP B.V.Inventors: Raymond Hamers, Cecile Hamers-Casterman, Serge V. M. Muyldermans, Leon G. J. Frenken, Cornelis T Verrips