Abstract: The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
Type:
Grant
Filed:
October 6, 2011
Date of Patent:
March 12, 2019
Assignees:
BAGI RESEARCH LIMITED, VERSITECH LIMITED
Inventors:
Stanley Chi Chung Chik, Anna Hing-Yee Law, Cindy Lai Hung Yang, Maureen Lau
Abstract: The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor. In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor, as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
January 9, 2018
Assignees:
BAGI RESEARCH LIMITED, VERSITECH LIMITED
Inventors:
Allan Sik Yin Lau, Lai Hung Cindy Yang, Stanley Chi Chung Chik
Abstract: The subject invention provides novel and advantageous materials and methods for treating neuroinflammation, neurodegenerative disease, and cerebrovascular disease by modulating TNF-? and/or nitric oxide production. Specifically exemplified herein is the therapeutic use of senkyunolide A (Sen A) and Z-ligustilide (Z-Lig), compounds isolated from traditional Chinese medicinal material Ligusticum chuanxiong (LCX).
Type:
Grant
Filed:
January 12, 2011
Date of Patent:
May 23, 2017
Assignees:
VERSITECH LIMITED, BAGI RESEARCH LIMITED
Inventors:
Allan Sik Yin Lau, Lai Hung Cindy Yang, Cho Tsun Or
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
December 22, 2015
Assignees:
BAGI RESEARCH LIMITED, VERSITECH LIMITED
Inventors:
Allan Sik Yin Lau, Lai Hung Cindy Yang, Stanley Chi Chung Chik
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Grant
Filed:
February 18, 2013
Date of Patent:
November 3, 2015
Assignees:
VERSITECH LIMITED, BAGI RESEARCH LIMITED
Inventors:
Allan Sy Lau, Lai Hung Cindy Yang, Chi Chung Stanley Chik, Chun Bong James Li