Abstract: The present invention discloses proteinaceous compounds that comprise at least a biologically active portion of a taipan natriuretic peptide (TNP) or a variant or derivative thereof. The invention also relates to the use of these compounds in methods for stimulating vasodilation, natriuresis, diuresis, renin-suppression, bactericidal activity, weight-loss or bone growth in a mammalian host. In specific embodiments, the compounds are useful in the treatment of congestive heart failure.
Type:
Application
Filed:
November 10, 2011
Publication date:
July 12, 2012
Applicants:
BAKER HEART RESEARCH INSTITUTE, THE UNIVERSITY OF QUEENSLAND
Inventors:
Paul Alewood, Geoffrey A. Head, Brian Fry
Abstract: The present invention discloses proteinaceous compounds that comprise at least a biologically active portion of a taipan natriuretic peptide (TNP) or a variant or derivative thereof. The invention also relates to the use of these compounds in methods for stimulating vasodilation, natriuresis, diuresis, renin-suppression, bactericidal activity, weight-loss or bone growth in a mammalian host. In specific embodiments, the compounds are useful in the treatment of congestive heart failure.
Type:
Grant
Filed:
January 15, 2007
Date of Patent:
November 15, 2011
Assignees:
The University of Queensland, Baker Heart Research Institute
Inventors:
Paul Alewood, Geoffrey A. Head, Bryan Fry
Abstract: The present invention discloses proteinaceous compounds that comprise at least a biologically active portion of a taipan natriuretic peptide (TNP) or a variant or derivative thereof. The invention also relates to the use of these compounds in methods for stimulating vasodilation, natriuresis, diuresis, renin-suppression, bactericidal activity, weight-loss or bone growth in a mammalian host. In specific embodiments, the compounds are useful in the treatment of congestive heart failure.
Type:
Application
Filed:
January 15, 2007
Publication date:
June 26, 2008
Applicants:
The University of Queensland, Baker Heart Research Institute
Inventors:
Paul Alewood, Geoffrey A. Head, Bryan Fry