Abstract: Disclosed herein are three-dimensional cage molecules, wherein the cage molecule is composed of RNA. Also disclosed is a composition including the three-dimensional cage molecule, as well as a pharmaceutical composition containing the three-dimensional cage molecule. Also disclosed herein are methods of administering a cage molecule, composition, or formulation thereof to a subject in need thereof.
Type:
Grant
Filed:
May 10, 2017
Date of Patent:
February 8, 2022
Assignees:
Ohio State Innovation Foundation, Ball State University
Inventors:
Peixuan Guo, Daniel Jasinski, Hui Li, Emil Khisamutdinov
Abstract: The present disclosure relates generally to carbon to carbon coupling processes, and more specifically, to dimerization or trimerization by electrocatalysis of alkenes and alkynes at room temperature.
Type:
Application
Filed:
April 3, 2013
Publication date:
October 10, 2013
Applicant:
Ball State University Board of Trustees
Abstract: Methods for measuring expansion of a test sample. One method includes establishing a diffraction slit between two blades, with the position of at least one of the blades being dependent upon the length of a test sample of material. As the temperature of the sample changes, the width of the slit changes. Light is projected through the slit onto a target and an diffraction pattern is measured. Changes in the light diffraction pattern correspond to the thermal expansion of the sample. Another method includes establishing a diffraction slit between two blades, with the position of at least one of the blades being dependent upon a length along a test sample of material. As a load is applied to the test sample, the width of the slit changes. Changes in the light diffraction pattern correspond to Young's Modulus for the sample.
Abstract: The invention provides novel lavendamycin analogs having the following general formula: and quinoline-5,8-diones having the following formula: Methods of making and using and compositions containing these compounds are also disclosed.
Abstract: The invention provides novel lavendamycin analogs having the following general formula:
and quinoline-5,8-diones having the following formula:
Methods of making and using and compositions containing these compounds are also disclosed.
Abstract: The invention provides novel lavendamycin analogs having the following general formula: ##STR1## and quinoline-5,8-diones having the following formula: ##STR2## Methods of making and using and compositions containing these compounds are also disclosed.
Abstract: The invention provides quinoline-5,8-diones having the following formula: ##STR1## wherein X, Z and R.sup.1 through R.sup.3 are defined in the specification, and salts of these quinolinediones. The invention also provides a method of making the quinolinediones. The quinolinediones have antitumor activity.
Abstract: The invention provides lavendamycin analogs having the following formula: ##STR1## wherein X, Y and R.sup.1 through R.sup.9 are defined in the specification, and salts of these analogs. The invention also provides a method of making the lavendamycin analogs. The lavendamycin analogs have antitumor and antimicrobial activity. Also, methods of treating cancer using lavendamycin methyl ester, 7-butyramido-2-methylquinoline-5,8-dione or 7-butyramido-2-formylquinoline-5,8-dione.
Abstract: A drawing receptacle can be adapted for use with the drawing output of such computer-directed printers, such as a laser printer. Such drawing receptacles can comprise a base, drawing retention means located about the base forming an open receptacle top and being adapted to retain drawings inserted into the open receptacle top, and a receptacle floor which is yieldably carried by the drawing receptacle above its base and within the drawing retention means and which is adapted to support drawing stacks of variable quantity.