Abstract: The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.

Abstract: A catheter includes a tubular body having a channel having its ends opening out respectively at the ends of the tubular body, injector element for injecting fluid into the channel, a tubular endpiece having a channel with ends opening out respectively at the ends of the tubular endpiece, and element for connecting the endpiece and the body together so that the end of the channel and the end of the channel are in alignment on an axis, the connection element being constituted essentially by a ring that partially covers the body and the endpiece, and being also arranged in such a manner that the connection can be broken by exerting a force couple of predetermined value respectively on the endpiece and on the body. The invention is applicable to safety catheters for performing endovascular treatments by injecting embolic fluid, for example for treating arteriovenous malfunctions.

Abstract: A catheter includes a tubular body having a channel having its ends opening out respectively at the ends of the tubular body, injector element for injecting fluid into the channel, a tubular endpiece having a channel with ends opening out respectively at the ends of the tubular endpiece, and element for connecting the endpiece and the body together so that the end of the channel and the end of the channel are in alignment on an axis, the connection element being constituted essentially by a ring that partially covers the body and the endpiece, and being also arranged in such a manner that the connection can be broken by exerting a force couple of predetermined value respectively on the endpiece and on the body. The invention is applicable to safety catheters for performing endovascular treatments by injecting embolic fluid, for example for treating arteriovenous malfunctions.