Abstract: An in vitro diagnostic (IVD) device is used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, and/or cerebrospinal fluid (CSF). An IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format, either to a display device or to a storage device internal or external to the IVD.
Abstract: The present invention relates to an exemplary in vitro diagnostic (IVD) device used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, cerebrospinal fluid (CSF). The inventive IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format wither to a display device or to a storage device internal or external to the IVD.
Abstract: The present invention relates to an exemplary in vitro diagnostic (IVD) device used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, cerebrospinal fluid (CSF). The inventive IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format wither to a display device or to a storage device internal or external to the IVD.
Type:
Application
Filed:
May 11, 2012
Publication date:
October 9, 2014
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC., BANYAN BIOMARKERS, INC.
Inventors:
Ronald Lawrence Hayes, Ka-Wang (Kevin) Wang, Andreas Jeromin, Ming-Cheng Liu, Monika Oli
Abstract: An in vitro diagnostic (IVD) device is used to detect the presence of and/or severity of liver injury in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of liver injury in a biological sample, such as whole blood, plasma, serum. The inventive IVD device may measure one or more of several specific markers in a biological sample and output the results to a machine readable format wither to a display device or to a storage device internal or external to the IVD.
Abstract: The present invention identifies biomarkers that are diagnostic of neural injury, neuronal disorder or neurotoxicity and is related to the discovery that proteases are selectively activated in subjects suffering from nervous system damage as compared to healthy subjects. Breakdown products reflecting protease activation are produced and detection of these different biomarkers of the invention is also diagnostic of the degree of severity and type of nerve damage in a subject.
Type:
Application
Filed:
July 22, 2013
Publication date:
January 23, 2014
Applicant:
Banyan Biomarkers, Inc.
Inventors:
Firas Kobeissy, Joy Guingab, Kevin Ka-Wang Wang, Ronald L. Hayes
Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
Type:
Grant
Filed:
August 5, 2009
Date of Patent:
October 15, 2013
Assignees:
University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
Inventors:
Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
Type:
Grant
Filed:
June 24, 2010
Date of Patent:
July 23, 2013
Assignees:
University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
Inventors:
Ka-Wang (Kevin) Wang, Ming-Cheng Liu, Monika Oli
Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
Type:
Application
Filed:
December 27, 2011
Publication date:
August 2, 2012
Applicants:
Banyan Biomarkers, Inc., University of Florida Research Foundation, Inc.
Inventors:
ANDREW K. OTTENS, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
Abstract: The present invention identities biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
Type:
Application
Filed:
November 19, 2010
Publication date:
July 21, 2011
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., BANYAN BIOMARKERS, INC.
Inventors:
KA-WANG (KEVIN) WANG, Ming-Cheng Liu, Monika Oli
Abstract: Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.
Type:
Application
Filed:
January 12, 2010
Publication date:
August 5, 2010
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., BANYAN BIOMARKERS, INC.
Inventors:
STANISLAV I. SVETLOV, RONALD L. HAYES, KA-WANG (KEVIN) WANG, MONIKA OLI
Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
Type:
Application
Filed:
August 5, 2009
Publication date:
February 25, 2010
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., BANYAN BIOMARKERS, INC.
Inventors:
Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
Type:
Grant
Filed:
April 15, 2005
Date of Patent:
November 25, 2008
Assignees:
University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
Inventors:
Kevin Ka-Wang Wang, Ronald Hayes, Ming Chen Liu, Monika Oli
Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
Type:
Grant
Filed:
April 15, 2005
Date of Patent:
July 8, 2008
Assignees:
University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
Inventors:
Ronald Hayes, Kevin Ka-Wang Wang, Ming Chen Liu, Monika Oli